COX-1/2-IN-12
COX-1/2-IN-12 is an orally active dual inhibitor of COX-1 and COX-2, with an IC50 of 41.6 nM against human COX-1 and an IC50 of 31.1 nM against human COX-2. COX-1/2-IN-12 induces antinociceptive activity and inhibits edema in in vivo experiments. COX-1/2-IN-12 can be used in research related to inflammation and pain.
For research use only. We do not sell to patients.
- CAS No.: 3068797-68-9
- Formula: C21H17F3N4O2S
- Molecular Weight:446.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human COX-1 41.6 nM (IC50) |
Human COX-2 31.1 nM (IC50) |
COX-1/2-IN-12 (Compound 73) (1-100 μM) carries an inherently low risk of hERG-mediated cardiotoxicity, with an hERG IC50 greater than 3 μM and complete solubility at a concentration of 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
COX-1/2-IN-12 (10 mg/kg; p.o.; single administration) exhibits potent and long-lasting anti-inflammatory activity in a carrageenan-induced rat paw edema model, reducing the degree of edema[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (SPF-grade)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Reduced the number of writhing events to 10 times (compared to vehicle control's 37.5 times).
Prolonged the latency period to 7 minutes (compared to vehicle control's 3.3 min).
Achieved statistically significant efficacy.
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Animal Model:Rat (SPF-grade)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Reduced paw swelling volume to 0.377 mL at 1 h, 0.276 mL at 2 h, 0.202 mL at 4 h, and 0.158 mL at 8 h, compared to model control's 0.536 mL at 1 h, 0.432 mL at 2 h, 0.376 mL at 4 h, and 0.303 mL at 8 h.
Chemical Information
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CAS No. 3068797-68-9
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Molecular Weight 446.45
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Formula C21H17F3N4O2S
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SMILES
CC(C1=C(C=C(N=C21)C(C=C3)=CC=C3S(N)(=O)=O)C(F)(F)F)=NN2CC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-1/2-IN-12 Related Classifications
HY-183673 Related Classifications
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