2. Immunology/Inflammation
  3. COX
  4. VU0487836

VU0487836 is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 serves as a prototype for the development of radiological imaging agents targeting COX-1 for ovarian cancer. VU0487836 is applicable to relevant research on ovarian cancer.

For research use only. We do not sell to patients.

VU0487836

VU0487836 Chemical Structure

CAS No. : 1632301-78-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

VU0487836 Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VU0487836 is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 serves as a prototype for the development of radiological imaging agents targeting COX-1 for ovarian cancer. VU0487836 is applicable to relevant research on ovarian cancer[1].

IC50 & Target[1]

Ovine COX-1

0.36 μM (IC50)

In Vitro

VU0487836 (compound 27) potently and selectively inhibits purified ovine COX-1 with an IC50 of 0.36 μM, while it shows no inhibitory activity against purified murine COX-2 (IC50 >25 μM)[1].
VU0487836 potently and selectively inhibits COX-1 in human ovarian cancer cell line OVCAR3 with an IC50 of 0.18 μM, while it shows no inhibitory activity against COX-2 in human 1483 head and neck squamous cell carcinoma cells (IC50 >5 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU0487836 Related Antibodies
Molecular Weight

284.29

Formula

C17H13FO3
CAS No.
SMILES

O=C1OCC(C=2C=CC(OC)=CC2)=C1C3=CC=CC(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

VU0487836 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04878361632301-78-0VU 0487836VU-0487836COXCyclooxygenasehuman ovarian cancer cellsCOX-2COX-1ovarian cancer1483 HNSCC cellsmurine COX-2ovine COX-1cyclooxygenase-1OVCAR3 cellsprostaglandinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
VU0487836
Cat. No.:
HY-126453
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.