2. Immunology/Inflammation
  3. COX
  4. VU0487836

VU0487836 is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 serves as a prototype for the development of radiological imaging agents targeting COX-1 for ovarian cancer. VU0487836 is applicable to relevant research on ovarian cancer.

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VU0487836

VU0487836 Chemical Structure

CAS No. : 1632301-78-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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VU0487836 Related Antibodies

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View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

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Description

VU0487836 is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 serves as a prototype for the development of radiological imaging agents targeting COX-1 for ovarian cancer. VU0487836 is applicable to relevant research on ovarian cancer[1].

IC50 & Target[1]

Ovine COX-1

0.36 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
OVCAR-3 IC50
0.18 μM
Compound: 27
Inhibition of COX-1 in human OVCAR3 cells by cell-based assay
Inhibition of COX-1 in human OVCAR3 cells by cell-based assay
[PMID: 25408841]
In Vitro

VU0487836 (compound 27) potently and selectively inhibits purified ovine COX-1 with an IC50 of 0.36 μM, while it shows no inhibitory activity against purified murine COX-2 (IC50 >25 μM)[1].
VU0487836 potently and selectively inhibits COX-1 in human ovarian cancer cell line OVCAR3 with an IC50 of 0.18 μM, while it shows no inhibitory activity against COX-2 in human 1483 head and neck squamous cell carcinoma cells (IC50 >5 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU0487836 Related Antibodies
Molecular Weight

284.29

Formula

C17H13FO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OCC(C=2C=CC(OC)=CC2)=C1C3=CC=CC(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (175.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5175 mL 17.5877 mL 35.1753 mL
5 mM 0.7035 mL 3.5175 mL 7.0351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5175 mL 17.5877 mL 35.1753 mL 87.9384 mL
5 mM 0.7035 mL 3.5175 mL 7.0351 mL 17.5877 mL
10 mM 0.3518 mL 1.7588 mL 3.5175 mL 8.7938 mL
15 mM 0.2345 mL 1.1725 mL 2.3450 mL 5.8626 mL
20 mM 0.1759 mL 0.8794 mL 1.7588 mL 4.3969 mL
25 mM 0.1407 mL 0.7035 mL 1.4070 mL 3.5175 mL
30 mM 0.1173 mL 0.5863 mL 1.1725 mL 2.9313 mL
40 mM 0.0879 mL 0.4397 mL 0.8794 mL 2.1985 mL
50 mM 0.0704 mL 0.3518 mL 0.7035 mL 1.7588 mL
60 mM 0.0586 mL 0.2931 mL 0.5863 mL 1.4656 mL
80 mM 0.0440 mL 0.2198 mL 0.4397 mL 1.0992 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8794 mL
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VU0487836 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04878361632301-78-0VU 0487836VU-0487836COXCyclooxygenasehuman ovarian cancer cellsCOX-2COX-1ovarian cancer1483 HNSCC cellsmurine COX-2ovine COX-1cyclooxygenase-1OVCAR3 cellsprostaglandinInhibitorinhibitorinhibit

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