VU0487836
Based on 1 Customer Validation
VU0487836 is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 serves as a prototype for the development of radiological imaging agents targeting COX-1 for ovarian cancer. VU0487836 is applicable to relevant research on ovarian cancer.
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- Purity: 99.86%
- CAS No.: 1632301-78-0
- 화학식: C17H13FO3
- 분자량:284.29
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Ovine COX-1 0.36 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OVCAR-3 | IC50 |
0.18 μM
Compound: 27
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Inhibition of COX-1 in human OVCAR3 cells by cell-based assay
Inhibition of COX-1 in human OVCAR3 cells by cell-based assay
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[PMID: 25408841] |
VU0487836 (compound 27) potently and selectively inhibits purified ovine COX-1 with an IC50 of 0.36 μM, while it shows no inhibitory activity against purified murine COX-2 (IC50 >25 μM)[1].
VU0487836 potently and selectively inhibits COX-1 in human ovarian cancer cell line OVCAR3 with an IC50 of 0.18 μM, while it shows no inhibitory activity against COX-2 in human 1483 head and neck squamous cell carcinoma cells (IC50 >5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1632301-78-0
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Appearance Solid
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분자량 284.29
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화학식 C17H13FO3
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Color Light yellow to yellow
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SMILES
O=C1OCC(C=2C=CC(OC)=CC2)=C1C3=CC=CC(F)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (175.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5175 mL | 17.5877 mL | 35.1753 mL | 87.9384 mL |
| 5 mM | 0.7035 mL | 3.5175 mL | 7.0351 mL | 17.5877 mL | |
| 10 mM | 0.3518 mL | 1.7588 mL | 3.5175 mL | 8.7938 mL | |
| 15 mM | 0.2345 mL | 1.1725 mL | 2.3450 mL | 5.8626 mL | |
| 20 mM | 0.1759 mL | 0.8794 mL | 1.7588 mL | 4.3969 mL | |
| 25 mM | 0.1407 mL | 0.7035 mL | 1.4070 mL | 3.5175 mL | |
| 30 mM | 0.1173 mL | 0.5863 mL | 1.1725 mL | 2.9313 mL | |
| 40 mM | 0.0879 mL | 0.4397 mL | 0.8794 mL | 2.1985 mL | |
| 50 mM | 0.0704 mL | 0.3518 mL | 0.7035 mL | 1.7588 mL | |
| 60 mM | 0.0586 mL | 0.2931 mL | 0.5863 mL | 1.4656 mL | |
| 80 mM | 0.0440 mL | 0.2198 mL | 0.4397 mL | 1.0992 mL | |
| 100 mM | 0.0352 mL | 0.1759 mL | 0.3518 mL | 0.8794 mL |
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