2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX
  5. COX-1 Isoform
  6. COX-1 Inhibitor

COX-1 Inhibitor

COX-1 Inhibitors (112):

Cat. No. Product Name Effect Purity
  • HY-66005
    Acetaminophen
    		Inhibitor 99.98%
    Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.
  • HY-14397
    Indomethacin
    		Inhibitor 99.97%
    Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.
  • HY-14398
    Celecoxib
    		Inhibitor 99.59%
    Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.
  • HY-14654
    Aspirin
    		Inhibitor 99.66%
    Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively.
  • HY-15036
    Diclofenac
    		Inhibitor 99.91%
    Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively.
  • HY-121828
    TX-1123
    		Inhibitor
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC.
  • HY-148224
    Pifoxime
    		Inhibitor
    Pifoxime is a COX-1/2 inhibitor, a non-steroidal anti-inflammatory agent (NSAID).
  • HY-78131
    Ibuprofen
    		Inhibitor 99.95%
    Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM.
  • HY-B1227
    Carprofen
    		Inhibitor 99.96%
    Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
  • HY-N0898
    Catechin
    		Inhibitor 99.57%
    Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
  • HY-15037
    Diclofenac Sodium
    		Inhibitor 99.92%
    Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively.
  • HY-N1067
    Xanthohumol
    		Inhibitor 99.84%
    Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities.
  • HY-N0001
    (-)-Epicatechin
    		Inhibitor 99.0%
    (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM.
  • HY-B0261
    Meloxicam
    		Inhibitor 99.70%
    Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
  • HY-15030
    Naproxen
    		Inhibitor 99.99%
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
  • HY-B0227
    Ketoprofen
    		Inhibitor 99.93%
    Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent.
  • HY-N0002
    (-)-Epicatechin gallate
    		Inhibitor 98.57%
    (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.
  • HY-59105
    SC-560
    		Inhibitor 99.80%
    SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.
  • HY-N0147
    Rutaecarpine
    		Inhibitor 99.00%
    Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.
  • HY-B0253
    Piroxicam
    		Inhibitor 99.71%
    Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.