84-26-4
Chemical Structure
Rutaecarpine
Synonym(s): Rutecarpine
- CAS No.: 84-26-4
- Formula:C18H13N3O
- Molecular Weight:287.32
IUPAC Name: 8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
InChIKey: ACVGWSKVRYFWRP-UHFFFAOYSA-N
SMILES: O=C1N2C(C(NC3=C4C=CC=C3)=C4CC2)=NC5=C1C=CC=C5
Biological Activity: Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
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Rutaecarpine | 99.77% | Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB). | ||||||||||||||||||||
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Rutaecarpine (Standard) | ≥98% | Rutaecarpine (Standard) is the analytical standard of Rutaecarpine. This product is intended for research and analytical applications. Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB). | ||||||||||||||||||||
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-
Similarity Score 0.80
HY-N16311-Hydroxyrutecarpine -
Similarity Score 0.78
HY-N27447beta-Hydroxyrutaecarpine -
Similarity Score 0.70
HY-N2106RDehydroevodiamine (Standard) -
Similarity Score 0.68
HY-N10149Nauclefine -
Similarity Score 0.62
HY-119458Luotonin A -
Similarity Score 0.61
HY-N16779Angustine -
Similarity Score 0.60
HY-N166471-O-β-D-Glucopyranosylrutaecarpine -
Similarity Score 0.57
HY-173230ABCA1 inducer 2 -
Similarity Score 0.54
HY-182816Topoisomerase I-IN-22 -
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