84-26-4
84-26-4
Chemical Structure
Rutaecarpine
Synonym(s): Rutecarpine
- CAS No.: 84-26-4
- Formula:C18H13N3O
- Molecular Weight:287.32
IUPAC Name: 8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
InChIKey: ACVGWSKVRYFWRP-UHFFFAOYSA-N
SMILES: O=C1N2C(C(NC3=C4C=CC=C3)=C4CC2)=NC5=C1C=CC=C5
Biological Activity: Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rutaecarpine | 99.77% | Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB). | ||||||||||||||||||||
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Rutaecarpine (Standard) | ≥98% | Rutaecarpine (Standard) is the analytical standard of Rutaecarpine. This product is intended for research and analytical applications. Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB). | ||||||||||||||||||||
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Luotonin A | 99.81% | Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity. | ||||||||||||||||||||
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ABCA1 inducer 2 | 98.22% | ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential. | ||||||||||||||||||||
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Topoisomerase I-IN-22 | Topoisomerase I-IN-22 is an inhibitor of MRSA DNA Topoisomerase I with an IC50 of 0.85 μg/mL. Topoisomerase I-IN-22 can specifically disrupt the cell membrane structure of MRSA, enter the interior of bacteria and inhibit the activity of DNA Topoisomerase I, thereby interfering with the processes of DNA replication and transcription. Topoisomerase I-IN-22 can be used for the research of MRSA infection. | |||||||||||||||||||||
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Nauclefine | 99.65% | Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway. | ||||||||||||||||||||
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Cryptolepinone | Cryptolepinone is a quinone reductase activator with a CD (concentration required to double induction) value of 0.02 μg/mL and can be found in Sida acuta. In the mouse mammary organ culture assay, 10 μg/mL of Cryptolepinone inhibited 83.3% of the preneoplastic lesions induced by DMBA (HY-W011845). Cryptolepinone can be used in anti-cancer research. | |||||||||||||||||||||
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1-Hydroxyrutecarpine | 1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity. | |||||||||||||||||||||
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1-O-β-D-Glucopyranosylrutaecarpine | 1-O-β-D-Glucopyranosylrutaecarpine (Compound 2) is an alkaloid found in the leaves of Evodia rutaecarpa. | |||||||||||||||||||||
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Angustine | Angustine is a monoterpene indole alkaloid vasodilator. Angustine exhibits potent vasodilatory activity on isolated rat aorta at a concentration of 10 μM (vasodilation rate exceeding 90%). Angustine can be used in the study of diseases such as hypertension, cerebral vasospasm, and peripheral circulatory disorders. Angustine can be naturally extracted from the bark of Nauclea officinalis and is also present in plants of the genera Mitragyna, Uncaria, and Strychnos. | |||||||||||||||||||||
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Dehydroevodiamine (Standard) | ≥98% | Dehydroevodiamine Standard is the analytical standard of Dehydroevodiamine (HY-N2106). This product is intended for research and analytical applications. Dehydroevodiamine is a blood-brain barrier-permeable, orally effective AChE and BACE1 inhibitor (IC50 = 40.96 μM). Dehydroevodiamine is isolated and extracted from Evodia rutaecarpa. Dehydroevodiamine attenuates neurotoxicity through multiple targets by inhibiting BACE1 to block Aβ production, inhibiting AChE activity, scavenging ROS, and suppressing calcium influx. Dehydroevodiamine can be used for research on Alzheimer's disease, cerebral ischemia, vascular dementia, and other cognitive disorder-related diseases. | ||||||||||||||||||||
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7beta-Hydroxyrutaecarpine | 7beta-Hydroxyrutaecarpine is a Alkaloids product that can be isolated from the fruits of Euodia ruticarpa. | |||||||||||||||||||||
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