2. PROTAC MAPK/ERK Pathway
  3. Ligands for Target Protein for PROTAC p38 MAPK
  4. p38α ligand-1

P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h (HY-153932).

For research use only. We do not sell to patients.

p38α ligand-1

p38α ligand-1 Chemical Structure

CAS No. : 586379-64-8

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p38α ligand-1 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Description

P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h (HY-153932)[1].

IC50 & Target[1]

p38α

 

Molecular Weight

464.26

Formula

C21H16BrF2NO4
CAS No.
SMILES

O=C(C1=CC=C(C)C(N2C(C(Br)=C(C=C2C)OCC3=CC=C(C=C3F)F)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (215.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1540 mL 10.7698 mL 21.5397 mL
5 mM 0.4308 mL 2.1540 mL 4.3079 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1540 mL 10.7698 mL 21.5397 mL 53.8491 mL
5 mM 0.4308 mL 2.1540 mL 4.3079 mL 10.7698 mL
10 mM 0.2154 mL 1.0770 mL 2.1540 mL 5.3849 mL
15 mM 0.1436 mL 0.7180 mL 1.4360 mL 3.5899 mL
20 mM 0.1077 mL 0.5385 mL 1.0770 mL 2.6925 mL
25 mM 0.0862 mL 0.4308 mL 0.8616 mL 2.1540 mL
30 mM 0.0718 mL 0.3590 mL 0.7180 mL 1.7950 mL
40 mM 0.0538 mL 0.2692 mL 0.5385 mL 1.3462 mL
50 mM 0.0431 mL 0.2154 mL 0.4308 mL 1.0770 mL
60 mM 0.0359 mL 0.1795 mL 0.3590 mL 0.8975 mL
80 mM 0.0269 mL 0.1346 mL 0.2692 mL 0.6731 mL
100 mM 0.0215 mL 0.1077 mL 0.2154 mL 0.5385 mL
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p38α ligand-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38α ligand-1586379-64-8Ligands for Target Protein for PROTACp38 MAPKTarget Protein-binding MoietyInhibitorinhibitorinhibit

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