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Cat. No.: HY-153932

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NR-7h

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Based on 1 Customer Validation

NR-7h is a potent and selective p38α and p38β degrader with DC₅₀ values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively.
(Pink: p38α and p38β ligand (HY-403098); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

Purity: 96.88%
CAS No.: 2550399-06-7
Formula: C₄₈H₅₀BrF₂N₉O₈
Molecular Weight:998.87

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

NR-7h Chemical Structure

CAS No.: 2550399-06-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

NR-7h is a potent and selective p38α and p38β degrader with DC₅₀ values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively^[1]. (Pink: p38α and p38β ligand (HY-403098); Blue: Cereblon ligand (HY-103596); Black: linker).

All PROTACs Isoforms :

All p38 MAPK Isoforms :

Chemical Information

CAS No. 2550399-06-7
Appearance Solid
Molecular Weight 998.87
Formula C₄₈H₅₀BrF₂N₉O₈
Color Light yellow to yellow
SMILES

O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Donoghue C, et al. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. Eur J Med Chem. 2020 Sep 1;201:112451. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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References

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NR-7h

All PROTACs Isoforms

All p38 MAPK Isoforms