2550399-06-7
Chemical Structure
NR-7h
- CAS No.: 2550399-06-7
- Formula:C48H50BrF2N9O8
- Molecular Weight:998.87
InChIKey: BEMLUUUHZPFCBS-UHFFFAOYSA-N
SMILES: O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5
Biological Activity: NR-7h is a selective p38α/p38β MAPK PROTAC degrader with multiple activities including anti-leishmanial, anti-malarial, and anti-Mayaro virus properties. NR-7h induces specific degradation of p38α/p38β isoforms and p38-MAPK via the ubiquitin-proteasome system. NR-7h reduces the load of Leishmania donovani, modulates the cytokine profile toward a pro-inflammatory phenotype, and enhances the oxidative burst of macrophages. NR-7h inhibits the growth of Plasmodium falciparum in human red blood cells and merozoite invasion. NR-7h reduces the replication of Mayaro virus and the expression of E1 protein in primary human dermal fibroblasts. NR-7h can be used in studies related to parasitic infections, viral infections, and breast cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NR-7h | 96.88% | NR-7h is a selective p38α/p38β MAPK PROTAC degrader with multiple activities including anti-leishmanial, anti-malarial, and anti-Mayaro virus properties. NR-7h induces specific degradation of p38α/p38β isoforms and p38-MAPK via the ubiquitin-proteasome system. NR-7h reduces the load of Leishmania donovani, modulates the cytokine profile toward a pro-inflammatory phenotype, and enhances the oxidative burst of macrophages. NR-7h inhibits the growth of Plasmodium falciparum in human red blood cells and merozoite invasion. NR-7h reduces the replication of Mayaro virus and the expression of E1 protein in primary human dermal fibroblasts. NR-7h can be used in studies related to parasitic infections, viral infections, and breast cancer. | ||||||||||||||||||||
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- [1]. Singhal J, et al. Chemical degradation of Human p38-MAPK reveals it as a potential host target to combat parasitic infections by Leishmania donovani and Plasmodium falciparum. Communications biology. 2026 Jun 11. [Content Brief]
- [2]. Sugasti-Salazar M, et al. Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells. Viruses. 2021 Jun 17;13(6):1156. [Content Brief]
- [3]. Donoghue C, et al. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. European journal of medicinal chemistry. 2020 Sep 01;201:112451. [Content Brief]
Keywords
