p38 MAPK Degrader
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NR-7h
0 ImagesCat. No.: HY-153932CAS No.: 2550399-06-7NR-7h is a potent and selective PROTAC degrader that targets and degrades p38α/β MAPK via cereblon recruitment. In T47D and MDA-MB-231 cells, the DC50 values of NR-7h for degrading p38α are 24 nM and 27.2 nM, respectively, while those for degrading p38β are 48.47 nM and 48.90 nM, respectively. NR-7h blocks stress- and cytokine-induced p38α signaling pathways. NR-7h can be used in studies related to breast cancer, other cancers, visceral leishmaniasis, malaria, Mayaro fever, and coronavirus infection.
