SJF-8240
Based on 1 Customer Validation
SJF-8240 is a selective p38α and c-Met PROTAC degrader. SJF-8240 promotes the ubiquitination and selective degradation of p38α and c-Met. SJF-8240 is applicable to breast cancer-related research.
(Pink: p38α and c-Met ligand (HY-45124); Blue: VHL ligand (HY-125845); Black: linker (HY-W442078)).
For research use only. We do not sell to patients.
- Purity: 99.33%
- CAS No.: 2230821-68-6
- Formula: C58H65F2N7O11S
- Molecular Weight:1106.24
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
p38α |
c-Met |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
50 nM
Compound: Example 1
|
Protac activity at E3 ubiquitin ligase/p38alpha in human MDA-MB-231 cells assessed as p38alpha degradation after 4 hrs by ELISA
Protac activity at E3 ubiquitin ligase/p38alpha in human MDA-MB-231 cells assessed as p38alpha degradation after 4 hrs by ELISA
|
[PMID: 30783495] |
Chemical Information
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CAS No. 2230821-68-6
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Appearance Solid
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Molecular Weight 1106.24
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Formula C58H65F2N7O11S
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Color White to light yellow
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SMILES
FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (90.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019;10(1):131. Published 2019 Jan 10. [Content Brief]
[3]. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9040 mL | 4.5198 mL | 9.0396 mL | 22.5991 mL |
| 5 mM | 0.1808 mL | 0.9040 mL | 1.8079 mL | 4.5198 mL | |
| 10 mM | 0.0904 mL | 0.4520 mL | 0.9040 mL | 2.2599 mL | |
| 15 mM | 0.0603 mL | 0.3013 mL | 0.6026 mL | 1.5066 mL | |
| 20 mM | 0.0452 mL | 0.2260 mL | 0.4520 mL | 1.1300 mL | |
| 25 mM | 0.0362 mL | 0.1808 mL | 0.3616 mL | 0.9040 mL | |
| 30 mM | 0.0301 mL | 0.1507 mL | 0.3013 mL | 0.7533 mL | |
| 40 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5650 mL | |
| 50 mM | 0.0181 mL | 0.0904 mL | 0.1808 mL | 0.4520 mL | |
| 60 mM | 0.0151 mL | 0.0753 mL | 0.1507 mL | 0.3767 mL | |
| 80 mM | 0.0113 mL | 0.0565 mL | 0.1130 mL | 0.2825 mL |
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