3-Fluoro-desmethyl-cabozantinib
3-Fluoro-desmethyl-cabozantinib is an BCL6 ligand that can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961). 3-Fluoro-desmethyl-cabozantinib is also a p38α ligand that can be used to synthesize PROTACs, such as SJFα (HY-114404).
For research use only. We do not sell to patients.
- CAS No.: 849217-50-1
- Formula: C27H21F2N3O5
- Molecular Weight:505.47
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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p38α |
c-Met |
p38δ |
Chemical Information
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CAS No. 849217-50-1
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Appearance Solid
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Molecular Weight 505.47
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Formula C27H21F2N3O5
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Color Off-white to light yellow
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SMILES
O=C(C1(CC1)C(NC2=CC=C(C(F)=C2)OC3=C4C=C(OC)C(O)=CC4=NC=C3)=O)NC5=CC=C(C=C5)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (197.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9784 mL | 9.8918 mL | 19.7836 mL | 49.4589 mL |
| 5 mM | 0.3957 mL | 1.9784 mL | 3.9567 mL | 9.8918 mL | |
| 10 mM | 0.1978 mL | 0.9892 mL | 1.9784 mL | 4.9459 mL | |
| 15 mM | 0.1319 mL | 0.6595 mL | 1.3189 mL | 3.2973 mL | |
| 20 mM | 0.0989 mL | 0.4946 mL | 0.9892 mL | 2.4729 mL | |
| 25 mM | 0.0791 mL | 0.3957 mL | 0.7913 mL | 1.9784 mL | |
| 30 mM | 0.0659 mL | 0.3297 mL | 0.6595 mL | 1.6486 mL | |
| 40 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2365 mL | |
| 50 mM | 0.0396 mL | 0.1978 mL | 0.3957 mL | 0.9892 mL | |
| 60 mM | 0.0330 mL | 0.1649 mL | 0.3297 mL | 0.8243 mL | |
| 80 mM | 0.0247 mL | 0.1236 mL | 0.2473 mL | 0.6182 mL | |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1978 mL | 0.4946 mL |
3-Fluoro-desmethyl-cabozantinib Related Classifications
HY-45124 Related Classifications
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