3-Fluoro-desmethyl-cabozantinib

Cat. No.: HY-45124: Data Sheet
SDS
Handling Instructions
FAQs
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3-Fluoro-desmethyl-cabozantinib is an BCL6 ligand that can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961).

For research use only. We do not sell to patients.

3-Fluoro-desmethyl-cabozantinib Chemical Structure

CAS No. : 849217-50-1

Size		Stock
MOQ		Minimum order quantity
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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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Description

3-Fluoro-desmethyl-cabozantinib is an BCL6 ligand that can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961)^[1].

Molecular Weight

505.47

Formula

C₂₇H₂₁F₂N₃O₅

CAS No.

849217-50-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1(CC1)C(NC2=CC=C(C(F)=C2)OC3=C4C=C(OC)C(O)=CC4=NC=C3)=O)NC5=CC=C(C=C5)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (197.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9784 mL	9.8918 mL	19.7836 mL
5 mM	0.3957 mL	1.9784 mL	3.9567 mL
10 mM	0.1978 mL	0.9892 mL	1.9784 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (246 KB) SDS (252 KB) Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9784 mL	9.8918 mL	19.7836 mL	49.4589 mL
	5 mM	0.3957 mL	1.9784 mL	3.9567 mL	9.8918 mL
	10 mM	0.1978 mL	0.9892 mL	1.9784 mL	4.9459 mL
	15 mM	0.1319 mL	0.6595 mL	1.3189 mL	3.2973 mL
	20 mM	0.0989 mL	0.4946 mL	0.9892 mL	2.4729 mL
	25 mM	0.0791 mL	0.3957 mL	0.7913 mL	1.9784 mL
	30 mM	0.0659 mL	0.3297 mL	0.6595 mL	1.6486 mL
	40 mM	0.0495 mL	0.2473 mL	0.4946 mL	1.2365 mL
	50 mM	0.0396 mL	0.1978 mL	0.3957 mL	0.9892 mL
	60 mM	0.0330 mL	0.1649 mL	0.3297 mL	0.8243 mL
	80 mM	0.0247 mL	0.1236 mL	0.2473 mL	0.6182 mL
	100 mM	0.0198 mL	0.0989 mL	0.1978 mL	0.4946 mL