1. MAPK/ERK Pathway
    PROTAC
  2. p38 MAPK
    PROTAC
  3. SJFα

SJFα 

Cat. No.: HY-114404
Handling Instructions

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM.

For research use only. We do not sell to patients.

SJFα Chemical Structure

SJFα Chemical Structure

CAS No. : 2254609-27-1

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Description

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

IC50 & Target[1]

p38α

7.16 nM (DC50)

p38δ

299 nM (DC50)

PROTAC

 

Molecular Weight

1120.27

Formula

C₅₉H₆₇F₂N₇O₁₁S

CAS No.

2254609-27-1

SMILES

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[[email protected]@H](C(C)(C)C)C(N5[[email protected]](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SJFα
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