1. MAPK/ERK Pathway
    PROTAC
    Autophagy
  2. p38 MAPK
    PROTAC
    Autophagy
  3. SJFδ

SJFδ 

Cat. No.: HY-114405
Handling Instructions

SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ.

For research use only. We do not sell to patients.

SJFδ Chemical Structure

SJFδ Chemical Structure

CAS No. : 2254609-23-7

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Description

SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].

IC50 & Target

p38α

46.17 nM (DC50)

PROTAC

 

Molecular Weight

1168.27

Formula

C₆₂H₆₃F₂N₇O₁₂S

CAS No.

2254609-23-7

SMILES

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCOCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC([[email protected]@H]7C[[email protected]@H](O)CN7C([[email protected]@H](N8C(C9=CC=CC=C9C8)=O)C(C)C)=O)=O)=C%10)C%10=NC=C4)C=C3)=O)=O)C=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SJFδ
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