2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis SARS-CoV
  4. Remdesivir maleate

Remdesivir maleate (GS-5734 maleate) is a nucleoside analogue with effective antiviral activity. Remdesivir maleate can inhibit the synthesis of viral DNA or RNA. Remdesivir maleate can be used for the research of infection, such as SARS-CoV and MHV infection.

For research use only. We do not sell to patients.

CAS No. : 2250110-53-1

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Remdesivir maleate Related Antibodies

Top Publications Citing Use of Products

214 Publications Citing Use of MCE Remdesivir maleate

Bio/Physico-chemical Assay
Cell Proliferation/Viability Assay
IF

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Aug;25(8):1223-1234.  [Abstract]

    Virus titre expressed in ‘Luminescence relative light units (RLU)’ and genome copy analysis of d5 infected STs ± antiviral drug treatment (Rem = Remdesivir (1 μM; 3 h); NHC = Molnupiravir).

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Science. 2021 Nov 26;374(6571):1099-1106.  [Abstract]

    Time course measurements of cell viability of Huh-7.5 cells electroporated with WT or Nsp1 K164A/H165A double mutant (Nsp1mut) Gluc replicon RNA. Cells were seeded with 100 nM Remdesivir or vehicle and were washed in phosphate-buffered saline 24 hours before each respective time-point collection. Mock-electroporated cells were used as controls for post-electroporation cell viability. The dashed line indicates the limit of detection. N = 4. Error bars indicate SD.

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Nature. 2020 Jun;582(7813):561-565.  [Abstract]

    Remdesivir treatment showing the use of synSARS-CoV-2-GFP. Vero E6 cells were infected with synSARS-CoV-2-GFP (MOI = 0.01) and treated with 0.2 μM, 2 μM or without Remdesivir. DMSO was used as treatment in cells that were not incubated with Remdesivir. Mock, uninfected cells. At 48 h after infection, cells were analysed by fluorescence microscopy to detect GFP expression (left) and cell-culture supernatants were collected and titrated by TCID50 assay (right).

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Mar;30(3):269-271.  [Abstract]

    Remdesivir (0.21-5.56 μM) inhibits virus infection efficiently in a human cell line (human liver cancer Huh-7 cells), which is sensitive to 2019-nCoV.2.

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936.  [Abstract]

    Immunofluorescence of intracellular viral N protein. Intracellular expression of N protein was assessed by staining of infected Vero E6 cells with the polyclonal anti-N antibody (1:1000 dilution, green). Nuclei were stained with DAPI. CPE was shown in bright field. The results showed that Remdesivir (6.25 µmol/L) significantly inhibited N protein expression.

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    Description

    Remdesivir maleate (GS-5734 maleate) is a nucleoside analogue with effective antiviral activity. Remdesivir maleate can inhibit the synthesis of viral DNA or RNA. Remdesivir maleate can be used for the research of infection, such as SARS-CoV and MHV infection[1][2][3].

    In Vitro

    Remdesivir maleate inhibits MHV replication with an IC50 of 1.1 μM in infected delayed brain tumor (DBT) cells with MHV[1].
    Remdesivir maleate (2 μM, 2 h preinfection and 2 h postinfection) shows maximal inhibition in infected cells with MHV[1].
    Remdesivir maleate (1-10 μM, 24-72 h) decreases SARS-CoV and MERS-CoV viral titer in HAE cells[1].
    Remdesivir maleate inhibits 2019-nCoV with an EC50 of 0.77 μM and CC50 >100 μM[2].
    Remdesivir maleate shows antiviral activity with EC50 values of 3.3 μM, 4.7 μM, 32 μM, 3.7 μM and 9.2 μM for SARS-CoV-2 and its variants alpha, beta, gamma and delta, respectively[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Remdesivir maleate Related Antibodies
    In Vivo

    Remdesivir maleate (0.01-100 μM) reduces lung viral titers in mice models of WT and F480L + V557L SARS-CoV[1].
    Remdesivir maleate (10 mg/kg, i.v.) shows 100% protection against Ebola virus infection in nonhuman primate (NHP) models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    718.65

    Formula

    C31H39N6O12P
    CAS No.
    SMILES

    OC(/C=C\C(O)=O)=O.N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@@H]([C@H]([C@H]1O)O)COP(OC4=CC=CC=C4)(N[C@@H](C)C(OCC(CC)CC)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Remdesivir maleate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Remdesivir2250110-53-1GS-5734GS5734GS 5734DNA/RNA SynthesisSARS-CoVSARS coronavirusMHVMERS-CoVInhibitorinhibitorinhibit

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