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Remdesivir maleate

(Synonyms: GS-5734 maleate)
226 Cited Publications
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Based on 226 publication(s) in Google Scholar

Remdesivir maleate (GS-5734 maleate) is a nucleoside analogue with effective antiviral activity. Remdesivir maleate can inhibit the synthesis of viral DNA or RNA. Remdesivir maleate can be used for the research of infection, such as SARS-CoV and MHV infection.

For research use only. We do not sell to patients.

  • CAS No.: 2250110-53-1
  • Formula: C31H39N6O12P
  • Molecular Weight:718.65
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Remdesivir maleate Chemical Structure
    Remdesivir maleate Chemical Structure
  • Experimental Validation Results for Remdesivir maleate
  • Experimental Validation Results for Remdesivir maleate
  • Experimental Validation Results for Remdesivir maleate
  • Experimental Validation Results for Remdesivir maleate
  • Experimental Validation Results for Remdesivir maleate
CAS No.: 2250110-53-1
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  • Remdesivir maleate Chemical Structure
    Remdesivir maleate Chemical Structure
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    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Aug;25(8):1223-1234. [Abstract]

    Customer Validation
     Virus titre expressed in ‘Luminescence relative light units (RLU)’ and genome copy analysis of d5 infected STs ± antiviral drug treatment (Rem = Remdesivir (1 μM; 3 h); NHC = Molnupiravir).

  • 1/16

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Science. 2021 Nov 26;374(6571):1099-1106. [Abstract]

    Customer Validation
     Time course measurements of cell viability of Huh-7.5 cells electroporated with WT or Nsp1 K164A/H165A double mutant (Nsp1mut) Gluc replicon RNA. Cells were seeded with 100 nM Remdesivir or vehicle and were washed in phosphate-buffered saline 24 hours before each respective time-point collection. Mock-electroporated cells were used as controls for post-electroporation cell viability. The dashed line indicates the limit of detection. N = 4. Error bars indicate SD.

  • 1/16

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Immunofluorescence of intracellular viral N protein. Intracellular expression of N protein was assessed by staining of infected Vero E6 cells with the polyclonal anti-N antibody (1:1000 dilution, green). Nuclei were stained with DAPI. CPE was shown in bright field. The results showed that Remdesivir (6.25 µmol/L) significantly inhibited N protein expression.

  • 1/16

    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Nature. 2020 Jun;582(7813):561-565. [Abstract]

    Customer Validation
     Remdesivir treatment showing the use of synSARS-CoV-2-GFP. Vero E6 cells were infected with synSARS-CoV-2-GFP (MOI = 0.01) and treated with 0.2 μM, 2 μM or without Remdesivir. DMSO was used as treatment in cells that were not incubated with Remdesivir. Mock, uninfected cells. At 48 h after infection, cells were analysed by fluorescence microscopy to detect GFP expression (left) and cell-culture supernatants were collected and titrated by TCID50 assay (right).

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    Remdesivir maleate purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Mar;30(3):269-271. [Abstract]

    Customer Validation
     Remdesivir (0.21-5.56 μM) inhibits virus infection efficiently in a human cell line (human liver cancer Huh-7 cells), which is sensitive to 2019-nCoV.2.

  • Remdesivir maleate