1. Cell Cycle/DNA Damage
    Autophagy
    Apoptosis
    Anti-infection
  2. DNA/RNA Synthesis
    Autophagy
    Apoptosis
    HIV
  3. Hydroxyurea

Hydroxyurea (Synonyms: Hydroxycarbamide)

Cat. No.: HY-B0313 Purity: >98.0%
Handling Instructions

Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase.

For research use only. We do not sell to patients.

Hydroxyurea Chemical Structure

Hydroxyurea Chemical Structure

CAS No. : 127-07-1

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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5 g USD 78 In-stock
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Based on 5 publication(s) in Google Scholar

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Description

Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase.

In Vitro

Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

76.05

Formula

CH₄N₂O₂

CAS No.

127-07-1

SMILES

O=C(N)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1314.92 mM; Need ultrasonic)

H2O : 50 mg/mL (657.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.1492 mL 65.7462 mL 131.4924 mL
5 mM 2.6298 mL 13.1492 mL 26.2985 mL
10 mM 1.3149 mL 6.5746 mL 13.1492 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (32.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (32.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (32.87 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (1314.92 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

HydroxyureaHydroxycarbamideDNA/RNA SynthesisAutophagyApoptosisHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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Hydroxyurea
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