134865-70-6
134865-70-6
Chemical Structure
8-M-PDOT
Synonym(s): AH-002
- CAS No.: 134865-70-6
- Formula:C14H19NO2
- Molecular Weight:233.31
IUPAC Name: N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide
InChIKey: RVIGBTUDFAGRTQ-UHFFFAOYSA-N
SMILES: CCC(NC1CC2=C(C=CC=C2OC)CC1)=O
Biological Activity: 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].
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8-M-PDOT | 99.33% | 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity. | ||||||||||||||||||||
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8-M-PDOT (Standard) | ≥98% | 8-M-PDOT (Standard) is the analytical standard of 8-M-PDOT (HY-101358). This product is intended for research and analytical applications. 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity. | ||||||||||||||||||||
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References
- [1]. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86. [Content Brief]
- [2]. Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9(1):47-54. [Content Brief]
Keywords
