1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. 8-M-PDOT

8-M-PDOT (Synonyms: AH-002)

Cat. No.: HY-101358 Purity: >99.0%
Handling Instructions

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.

For research use only. We do not sell to patients.

8-M-PDOT Chemical Structure

8-M-PDOT Chemical Structure

CAS No. : 134865-70-6

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10 mM * 1 mL in DMSO USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 585 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

IC50 & Target

pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)[2]

In Vivo

8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (280-320 g) with Rotenone[2]
Dosage: 10 µg/µL
Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Result: Increased percentage of time spent in the open arms and in the number of open arms entries.
Molecular Weight

233.31

Formula

C₁₄H₁₉NO₂

CAS No.

134865-70-6

SMILES

CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (428.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2861 mL 21.4307 mL 42.8614 mL
5 mM 0.8572 mL 4.2861 mL 8.5723 mL
10 mM 0.4286 mL 2.1431 mL 4.2861 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 7.5 mg/mL (32.15 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (32.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

8-M-PDOTAH-002AH002AH 002Melatonin ReceptorRotenoneanxiolyticMT2Inhibitorinhibitorinhibit

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Product Name:
8-M-PDOT
Cat. No.:
HY-101358
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