1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. 8-M-PDOT

8-M-PDOT (Synonyms: AH-002)

Cat. No.: HY-101358
Handling Instructions

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.

For research use only. We do not sell to patients.

8-M-PDOT Chemical Structure

8-M-PDOT Chemical Structure

CAS No. : 134865-70-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 585 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

IC50 & Target

pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)[2]

In Vivo

8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2].

Animal Model: Male Wistar rats (280-320 g) with Rotenone[2]
Dosage: 10 µg/µL
Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Result: Increased percentage of time spent in the open arms and in the number of open arms entries.
Molecular Weight

233.31

Formula

C₁₄H₁₉NO₂

CAS No.

134865-70-6

SMILES

CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

8-M-PDOTAH-002AH002AH 002Melatonin ReceptorRotenoneanxiolyticMT2Inhibitorinhibitorinhibit

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8-M-PDOT
Cat. No.:
HY-101358
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