1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. Luzindole

Luzindole (Synonyms: N-0774)

Cat. No.: HY-101254 Purity: 100.0%
Handling Instructions

Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity.

For research use only. We do not sell to patients.

Luzindole Chemical Structure

Luzindole Chemical Structure

CAS No. : 117946-91-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 193 Get quote
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 Get quote
10 mg USD 305 Get quote
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity[1][2][3].

IC50 & Target

Ki :10.2 nM (human MT2), 158 nM (human MT1)[1]

In Vitro

Luzindole (N-0774) (5-10 μg/ml) inhibits antigen-specific proliferation of the MBP-reactive LV-4 T cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Luzindole (N-0774) (30 mg/kg; i.p.; days 0-5) suppresses experimental autoimmune encephalomyelitis[2].
Luzindole (N-0774) (30 mg/kg i.p.) reduces the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Twenty-three- to 12-week-old(SJL X PL/J ) F1 mice[2]
Dosage: 30 mg/kg
Administration: i.p.; days 0-5 (between 23: 00 and 1: 00 under conditions of minimal lighting)
Result: Effectively prevented experimental autoimmune encephalomyelitis.
Molecular Weight

292.37

Formula

C₁₉H₂₀N₂O

CAS No.

117946-91-5

SMILES

CC(NCCC1=C(CC2=CC=CC=C2)NC3=C1C=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (855.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4203 mL 17.1016 mL 34.2032 mL
5 mM 0.6841 mL 3.4203 mL 6.8406 mL
10 mM 0.3420 mL 1.7102 mL 3.4203 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (21.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (21.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (21.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 100.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LuzindoleN-0774N0774N 0774Melatonin Receptorselectivepreferentiallyautoimmuneencephalomyelitisantidepressant-likesubtypeanti-immobilityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Luzindole
Cat. No.:
HY-101254
Quantity:
MCE Japan Authorized Agent: