1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. 2-Iodomelatonin

2-Iodomelatonin 

Cat. No.: HY-101176 Purity: >99.0%
Handling Instructions

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1  over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

For research use only. We do not sell to patients.

2-Iodomelatonin Chemical Structure

2-Iodomelatonin Chemical Structure

CAS No. : 93515-00-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 118 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1  over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

In Vitro

2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells[2].

Cell Viability Assay[2]

Cell Line: Mutant htt ST14A cell
Concentration: 0 μM; 1 μM; 5 μM; 7.5 μM
Incubation Time: 18 hours
Result: Inhibited mutant htt ST14A cell death.
Molecular Weight

358.17

Formula

C₁₃H₁₅IN₂O₂

CAS No.

93515-00-5

SMILES

CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

2-IodomelatoninMelatonin ReceptorlocalizemelatoninInhibitorinhibitorinhibit

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2-Iodomelatonin
Cat. No.:
HY-101176
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