1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. S-22153

S-22153 

Cat. No.: HY-114962
Handling Instructions

S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes.

For research use only. We do not sell to patients.

S-22153 Chemical Structure

S-22153 Chemical Structure

CAS No. : 180304-07-8

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Description

S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].

IC50 & Target[2]

MT1

19 nM (EC50)

MT2

4.6 nM (EC50)

In Vivo
Molecular Weight

247.36

Formula

C₁₄H₁₇NOS

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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S-22153
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HY-114962
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