1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. ACH-000143

ACH-000143 

Cat. No.: HY-138626
Handling Instructions

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.

For research use only. We do not sell to patients.

ACH-000143 Chemical Structure

ACH-000143 Chemical Structure

CAS No. : 2225836-30-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].

IC50 & Target[1]

MT1

0.06 nM (EC50)

MT2

0.32 nM (EC50)

In Vivo

ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].
ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].
ACH-000143 significantly reduces plasma glucose at 10 mg/kg (−16.4%, p < 0.05) and 30 mg/kg (−16.9%, p < 0.01)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet rats[1].
Dosage: 10 and 30 mg/kg.
Administration: Orally, once daily for two months.
Result: Significantly reduced the weekly BW gain on weeks.
Molecular Weight

297.74

Formula

C₁₃H₁₆ClN₃O₃

CAS No.
SMILES

CC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

ACH-000143ACH000143ACH 000143Melatonin ReceptorsteatosisHFDlowtoxicityobeseInhibitorinhibitorinhibit

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ACH-000143
Cat. No.:
HY-138626
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