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NFAT Inhibitor (Synonyms: VIVIT peptide)

Cat. No.: HY-P1026 Purity: 98.89%
Handling Instructions

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NFAT Inhibitor Chemical Structure

NFAT Inhibitor Chemical Structure

CAS No. : 249537-73-3

Size Price Stock Quantity
1 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 612 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

IC50 & Target

Nuclear factor of activated Tcells (NFAT)[1][2]

In Vitro

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9[2].

Western Blot Analysis[2]

Cell Line: Human peripheral blood CD14+ monocytes
Concentration: 10 μM
Incubation Time: 24 hours or 21 days
Result: Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
Molecular Weight

1685.94

Formula

C₇₅H₁₂₀N₂₀O₂₂S

CAS No.

249537-73-3

Sequence

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

Sequence Shortening

MAGPHPVIVITGPHEE

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (59.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5931 mL 2.9657 mL 5.9314 mL
5 mM 0.1186 mL 0.5931 mL 1.1863 mL
10 mM 0.0593 mL 0.2966 mL 0.5931 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NFAT InhibitorVIVIT peptideOthersNFATcell-permeabledephosphorylationtestosteroneNFAT-LucalcineurinMMP‐9TRAP cathepsin-KInhibitorinhibitorinhibit

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Product name:
NFAT Inhibitor
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HY-P1026
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