249537-73-3
249537-73-3
Chemical Structure
NFAT Inhibitor-1
Synonym(s): VIVIT peptide
- CAS No.: 249537-73-3
- Formula:C75H118N20O22S
- Molecular Weight:1683.93
InChIKey: QPMHUXBSHGAVGD-MCDIZDEASA-N
SMILES: O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@@H](N)CCSC)=O)=O)=O)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(NCC(N4[C@@H](CCC4)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NFAT Inhibitor-1 | 99.89% | NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. | ||||||||||||||||||||
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References
- [1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33. [Content Brief]
- [2]. Ma JD, et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264. [Content Brief]
