Big Endothelin-1 (22-38), human
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38).
For research use only. We do not sell to patients.
- CAS No.: 124932-61-2
- Formula: C80H125N23O25
- Molecular Weight:1808.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 124932-61-2
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Molecular Weight 1808.99
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Formula C80H125N23O25
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Sequence Shortening
VNTPEHVVPYGLGSPRS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hemsén A, et al. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21). Regul Pept. 1995 Feb 14;55(3):287-97. [Content Brief]
[2]. D'Orléans-Juste P, et al. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S251-5. [Content Brief]
[3]. Huneidi AH, et al. Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S492-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Big Endothelin-1 (22-38), human Related Classifications
HY-P3733 Related Classifications
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