1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. 5-HT Receptor nAChR
  3. Tropisetron

Tropisetron  (Synonyms: SDZ-ICS-930 free base)

Cat. No.: HY-B0072 Purity: 98.72%
COA Handling Instructions

Tropisetron (SDZ-ICS-930 free base) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.

For research use only. We do not sell to patients.

Tropisetron Chemical Structure

Tropisetron Chemical Structure

CAS No. : 89565-68-4

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10 mM * 1 mL in DMSO USD 55 In-stock
5 mg USD 32 In-stock
10 mg USD 50 In-stock
25 mg USD 90 In-stock
50 mg USD 160 In-stock
100 mg USD 280 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tropisetron:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tropisetron

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Tropisetron (SDZ-ICS-930 free base) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. IC50 value: 70.1 ± 0.9 nM [1] Target: 5-HT3 receptor in vitro: Tropisetron specifically inhibited both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. tropisetron inhibited both the binding to DNA and the transcriptional activity of NFAT and AP-1. We also observed that tropisetron is a potent inhibitor of PMA plus ionomycin-induced NF-(kappa)B activation but in contrast TNF(alpha)-mediated NF-(kappa)B activation was not affected by this antagonist [2]. Tropisetron prevents the phosphorylation and thus activation of the p38 MAPK, which is involved in post-transcriptional regulation of various cytokines [3]. in vivo: Two different doses of tropisetron (5 and 10 mg/kg) or vehicle were administered intraperitoneally 30 min before pMCAO. Neurological deficit scores, mortality rate and infarct volume were determined 24 h after permanent focal cerebral ischemia [4].

IC50 & Target

5-HT3 Receptor

70.1 nM (IC50)



Clinical Trial
Molecular Weight







White to light yellow




Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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