Tropisetron Hydrochloride
Based on 5 publication(s) in Google Scholar
Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC50 of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.92%
- CAS 番号: 105826-92-4
- 分子式: C17H21ClN2O2
- 分子量:320.81
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Tropisetron Hydrochloride
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生物活性
製品説明
IC50 & Target
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5-HT3 Receptor 70.1 nM (IC50) |
5-HT3 Receptor |
α7-nAChR |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
10 nM
Compound: Tropisetron ICS-205-930
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Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes
Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes
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[PMID: 15050614] |
体外実験
Tropisetron Hydrochloride (1-1000 nM, 1 h) has a neuroprotective effect against glutamate-induced excitotoxicity in pig retinal ganglion cells (RGCs), with an EC50 of 62 nM[1].
Tropisetron Hydrochloride (100 nM, 1 h) does not have a significant impact on the pAkt levels in RGCs, but it significantly lowers the p38 MAPK levels associated with excitotoxicity[1].
Tropisetron Hydrochloride (1 nM-10 mM, 4 days) inhibits phosphatase activity in cerebellar granule neurons (CGNs)[2].
Tropisetron Hydrochloride (1 nM-10 mM, 4 days) does not affect the viability of CGNs[2].
Tropisetron Hydrochloride (10 nM-10 μM, 4 days) inhibits phosphatase activity in CGNs, increases CB1 expression, and reduces cAMP levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Pig RGCs induced by glutamate[1]; CGNs[2]
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Concentration:1, 10, 50, 100, 1000 nM; 1, 10, 100, 1000, 10000, 100000, 1000000 nM
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Incubation Time:1 h; 4 days
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Result:Increased RGCs cell survival rate.
Had no effect on CGNs cell vitality at 1nM-10mM; higher doses reduced cell vitality.
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Cell Line:CGNs (rat)
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Concentration:100 nM, 1 μM, 10 μM
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Incubation Time:4 days
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Result:Inhibited the activity of calcineurin, increased the expression of CB1, and reduced cAMP levels.
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Cell Line:CGNs (rat)
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Concentration:100 nM, 1 μM, 10 μM
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Incubation Time:4 days
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Result:Inhibited the activity of calcineurin, increased the expression of CB1, and reduced cAMP levels.
体内実験
Tropisetron Hydrochloride (1 μg, ICV, single dose) reverses cognitive deficits in rats, providing protection against Ab (HY-P4867) induced neurotoxicity through both 5-HT3 receptor-dependent and independent pathways[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Beta-amyloid (Ab) rat model of AD[4]
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Dosage:1 μg, single dose
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Administration:Intracerebroventricular injection (ICV)
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Result:Increased in TNF-a, COX-2, iNOS, NF-κB, active caspase 3, cytochrome c release and calcineurin phosphatase activity in the hippocampus.
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Animal Model:Rxperimental autoimmune encephalomyelitis (EAE) mice induced by myelin oligodendrocyte glycoprotein peptide[3]
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Dosage:5 mg/kg, daily, 32 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Improved the clinical symptoms of EAE, suppressed the infiltration of inflammatory cells in the central nervous system and demyelination, significantly reduced the number and extent of inflammatory lesions and demyelinated areas, decreased the quantity and function of effector T cells, and inhibited the production of pro-inflammatory cytokines IL-17, IL-6, and IL-2.
化学情報
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CAS 番号 105826-92-4
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性状 Solid
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分子量 320.81
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分子式 C17H21ClN2O2
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Color White to off-white
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SMILES
O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3.[H]Cl
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別名
SDZ-ICS-930
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cancer Lett
Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer. [Abstract]2024 Sep 28:600:217150. PMID: 39097134 -
Acta Pharmacol Sin
Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice. [Abstract]2024 Sep;45(9):1821-1831. PMID: 38702501 -
Int J Neuropsychopharmacol
2019 Sep 1;22(9):574-584. PMID: 31125405 -
Drug Dev Res
Tropisetron attenuates high glucose-induced oxidative stress and inflammation in ARPE-19 cells in vitro via regulating SIRT1/ROCK1 signaling. [Abstract]2024 Nov;85(7):e70002. PMID: 39381984 -
Virus Res
Ondansetron exhibits potent antiviral activity against enterovirus 71 infection in vitro and in vivo. [Abstract]2026 Jun 25:370:199771. PMID: 42349797
溶剤 & 溶解度
体外:
DMSO : 70 mg/mL (218.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (155.86 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 120 mg/mL (374.05 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Swartz MM, et al. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21. [Content Brief]
[2]. Rahimian R, et al. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011 Oct 12;1417:1-8. [Content Brief]
[3]. Aminian A, et al. Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. Neuroscience. 2013 Jun 15;248C:299-306. [Content Brief]
[4]. Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013 Oct;43(10):1039-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.1171 mL | 15.5855 mL | 31.1711 mL | 77.9277 mL |
| 5 mM | 0.6234 mL | 3.1171 mL | 6.2342 mL | 15.5855 mL | |
| 10 mM | 0.3117 mL | 1.5586 mL | 3.1171 mL | 7.7928 mL | |
| 15 mM | 0.2078 mL | 1.0390 mL | 2.0781 mL | 5.1952 mL | |
| 20 mM | 0.1559 mL | 0.7793 mL | 1.5586 mL | 3.8964 mL | |
| 25 mM | 0.1247 mL | 0.6234 mL | 1.2468 mL | 3.1171 mL | |
| 30 mM | 0.1039 mL | 0.5195 mL | 1.0390 mL | 2.5976 mL | |
| 40 mM | 0.0779 mL | 0.3896 mL | 0.7793 mL | 1.9482 mL | |
| 50 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5586 mL | |
| 60 mM | 0.0520 mL | 0.2598 mL | 0.5195 mL | 1.2988 mL | |
| 80 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9741 mL | |
| 100 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tropisetron Hydrochloride 関連分類
HY-B0020 関連分類
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