1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. 5-HT Receptor
    COMT
  3. Flopropione

Flopropione 

Cat. No.: HY-100562 Purity: 98.37%
Handling Instructions

Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor. Flopropione also as an antispasmodic agent.

For research use only. We do not sell to patients.

Flopropione Chemical Structure

Flopropione Chemical Structure

CAS No. : 2295-58-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor[1][2]. Flopropione also as an antispasmodic agent[3].

IC50 & Target

5-HT1A receptor[1], COMT[2]

In Vivo

The effect of Flopropione as an antispasmodic agent on the rate of passing a calculus from the urinary tract has been compared retrospectively with patients in whom passage was spontaneous. Flopropine has been shown, with statistical significance, to be superior to the control in cumulative passage rate after initiation of administration. Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems[3].

Molecular Weight

182.17

Formula

C₉H₁₀O₄

CAS No.

2295-58-1

SMILES

CCC(C1=C(O)C=C(O)C=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (823.41 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4894 mL 27.4469 mL 54.8938 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL
10 mM 0.5489 mL 2.7447 mL 5.4894 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Flopropione5-HT ReceptorCOMTSerotonin Receptor5-hydroxytryptamine ReceptorCatechol-O-methyltransferaseInhibitorinhibitorinhibit

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Product name:
Flopropione
Cat. No.:
HY-100562
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