Cat. No.: HY-115385

Lumichrome

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway.

For research use only. We do not sell to patients.

Purity: 99.84%
CAS No.: 1086-80-2
Formula: C₁₂H₁₀N₄O₂
Molecular Weight:242.24

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Lumichrome Chemical Structure

CAS No.: 1086-80-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Akt Isoforms :

All NF-κB Isoforms :

All ERK Isoforms :

All p38 MAPK Isoforms :

In Vitro

Lumichrome (0-100 μM, 24 h) exhibits cytotoxicity in cancer cells H292, A549 and H460 (IC₅₀ = 38, 54 and 79 μM, respectively), induces apoptosis in these cells, and inhibits the colony formation^[2].
Lumichrome (0-10 μM, 5-28 days) inhibits RANKL-induced osteoclastogenesis and bone resorption through inhibition of NFAT/NF-κB/MAPK/calcium signaling pathways^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

H292, A549 and H460
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Inhibited cell viability.

Western Blot Analysis^[2]

Cell Line:

H292, A549 and H460
Concentration:

0-50 μM
Incubation Time:

24 h
Result:

Increased expression of cleaved PARP, caspase-3/9, increased expression of p53.

In Vivo

Lumichrome (7.5 mg/kg, ip, three times a week for 6 weeks) reduces bone loss and prevents osteoporosis in the ovariectomized (OVX) mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OVX mouse model^[3]
Dosage:

7.5 mg/kg
Administration:

ip, three times a week for 6 weeks
Result:

Increased bone mineral density (BMD) and bone volume fraction (BV/TV) in OVX mice, and reduced the osteoclast surface/bone surface (Oc.S/BS) ratio.

Chemical Information

CAS No. 1086-80-2
Appearance Solid
Molecular Weight 242.24
Formula C₁₂H₁₀N₄O₂
Color Light yellow to yellow
SMILES

O=C(N1)NC2=NC3=CC(C)=C(C)C=C3N=C2C1=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Journal Impact Factor

Chem Eng J

2025 Sep 15.
J Ethnopharmacol

Desmodium styracifolium (Osb.) Merr. Extracts alleviate cholestatic liver disease by FXR pathway. [Abstract]

2024 Oct 23:118972. PMID: 39454708

Solvent & Solubility

In Vitro:

DMSO : 2 mg/mL (8.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1281 mL

20.6407 mL

41.2814 mL

5 mM

0.8256 mL

4.1281 mL

8.2563 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70(9):574-580. [Content Brief]

[2]. Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71(8):1390-1402. [Content Brief]

[3]. Liu C, et al., Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling. J Cell Physiol. 2018 Nov;233(11):8971-8983. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1281 mL	20.6407 mL	41.2814 mL	103.2034 mL
DMSO	5 mM	0.8256 mL	4.1281 mL	8.2563 mL	20.6407 mL

Keywords

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Lumichrome

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

NF-κB Signaling Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Natural Product Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glycolysis Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Antihypertensive Compound Library

Cell Death Library

Serine/Threonine Kinase Inhibitor Library

Extracellular Vesicles (EVs) Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Miao Ethnicity Medicine Compound Library

Protein Kinase Compound Library

Vitamin Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Human Metabolite Library

Posttranslational Modification Library

Natural Product Diversity Scaffold Library

RNA Binding Bioactive Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Drug Fragment Library

MCE Kinase Hinge Binder Fragment Library

Publications Citing Use of MedChemExpress (MCE) Lumichrome

All Akt Isoforms

All NF-κB Isoforms

All ERK Isoforms