945614-12-0
945614-12-0
Chemical Structure
Pexmetinib
Synonym(s): ARRY-614
- CAS No.: 945614-12-0
- Formula:C31H33FN6O3
- Molecular Weight:556.63
IUPAC Name: 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea
InChIKey: LNMRSSIMGCDUTP-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
Biological Activity: Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pexmetinib | 99.81% | Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. | ||||||||||||||||||||
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Pexmetinib (Standard) | ≥98% | Pexmetinib (Standard) is the analytical standard of Pexmetinib. This product is intended for research and analytical applications. Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. | ||||||||||||||||||||
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Keywords
