DOPE (GMP Like)
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.
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- CAS No.: 4004-05-1
- Formule: C41H78NO8P
- Masse moléculaire:744.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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HY-112005
DOPEFerroptosis Inhibitor -
HY-113424A
1,2-Dioleoyl-sn-glycero-3-phosphocholinePhospholipid -
HY-W040193
DSPCLiposome Compound -
HY-112005G
DOPE (GMP)Ferroptosis Inhibitor -
HY-130463
POPG sodiumPhospholipid -
HY-112530
1,2-Distearoyl-sn-glycero-3-phosphorylethanolaminePhosphoethanolamine (PE) Lipid -
HY-22274
DMPG sodiumBiochemical Assay Reagent -
HY-141571
DOPG sodiumBiochemical Assay Reagent -
HY-109541
Colfosceril miristatePhospholipid Compound -
HY-109506
DPPCEndogenous Metabolite -
HY-130462
1-Palmitoyl-2-oleoyl-sn-glycero-3-PCSaturated Monobasic Alcohol -
HY-141613
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodiumPhosphoserine/Phosphatidylserine Ubstitute
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Activité biologique
Description
In Vitro
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 4004-05-1
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Masse moléculaire 744.03
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Formule C41H78NO8P
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SMILES
O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
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Synonyms
Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DOPE (GMP Like) Related Classifications
HY-112005GL Related Classifications
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