18:0,18:1 PS 

18:0,18:1 PS is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage^[1][2].

18:0,18:1 PS is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles^[1]:
(1) PS 18:0,18:1 accounts for approximately 22-60% of total PS in various cell lines including PC-3, HEp-2, PSA3 CHO, HeLa, MT4, A549 and mouse fibroblast cell lines.
(2) PS 18:0,18:1 accounts for approximately 40% of total PS species in exosomes derived from PC-3 cells, and theoretically covers about 80% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet^[1].
(3) PS 18:0,18:1 theoretically covers about 60% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet of HIV-1 particles.

The cross-intercalation between PS 18:0,18:1 and SM d18:1/24:0 is stronger than that between PS 16:0/18:1 (HY-146885), and it is the only tested PS species whose cross-intercalation with SM d18:1/24:0 is enhanced in the presence of cholesterol^[1].
PS 18:0,18:1 can co-drive phase separation with cholesterol in GUVs, and more effectively protect cholesterol from the action of cholesterol oxidase compared with PS 16:0/18:1, PS 18:1/18:1 and PS 16:0/18:2^[1].
PS 18:0,18:1 promotes the clustering of endogenous GPI-APs on the surface of PSA3 CHO cells, with an efficacy comparable to that of PS 18:0/18:0 and more potent than that of PS 18:1/18:1 or PS 12:0/12:0^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

18:0,18:1 PS is highly enriched in rat brain phosphatidylserine relative to heart, kidney, and liver, comprising 26% of total brain phosphatidylserine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

790.06

C₄₂H₈₀NO₁₀P

124262-93-7

Solid

White to off-white

OC([C@@H](N)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Skotland T, et al. The role of PS 18:0/18:1 in membrane function. Nat Commun. 2019;10(1):2752. Published 2019 Jun 21.  [Content Brief]

  [2]. Choi J, et al. Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids. Mol Cell Biochem. 2018;442(1-2):187-201.  [Content Brief]