18:0,18:1 PS

18:0,18:1 PS is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles^[1]:
(1) PS 18:0,18:1 accounts for approximately 22-60% of total PS in various cell lines including PC-3, HEp-2, PSA3 CHO, HeLa, MT4, A549 and mouse fibroblast cell lines.
(2) PS 18:0,18:1 accounts for approximately 40% of total PS species in exosomes derived from PC-3 cells, and theoretically covers about 80% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet^[1].
(3) PS 18:0,18:1 theoretically covers about 60% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet of HIV-1 particles.

The cross-intercalation between PS 18:0,18:1 and SM d18:1/24:0 is stronger than that between PS 16:0/18:1 (HY-146885), and it is the only tested PS species whose cross-intercalation with SM d18:1/24:0 is enhanced in the presence of cholesterol^[1].
PS 18:0,18:1 can co-drive phase separation with cholesterol in GUVs, and more effectively protect cholesterol from the action of cholesterol oxidase compared with PS 16:0/18:1, PS 18:1/18:1 and PS 16:0/18:2^[1].
PS 18:0,18:1 promotes the clustering of endogenous GPI-APs on the surface of PSA3 CHO cells, with an efficacy comparable to that of PS 18:0/18:0 and more potent than that of PS 18:1/18:1 or PS 12:0/12:0^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.