18:0,18:1 PS sodium
Based on 1 Customer Validation
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 321883-23-2
- Formula: C42H79NNaO10P
- Molecular Weight:812.04
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles[1]:
(1) PS 18:0,18:1 accounts for approximately 22-60% of total PS in various cell lines including PC-3, HEp-2, PSA3 CHO, HeLa, MT4, A549 and mouse fibroblast cell lines.
(2) PS 18:0,18:1 accounts for approximately 40% of total PS species in exosomes derived from PC-3 cells, and theoretically covers about 80% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet[1].
(3) PS 18:0,18:1 theoretically covers about 60% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet of HIV-1 particles.
The cross-intercalation between PS 18:0,18:1 and SM d18:1/24:0 is stronger than that between PS 16:0/18:1 (HY-146885), and it is the only tested PS species whose cross-intercalation with SM d18:1/24:0 is enhanced in the presence of cholesterol[1].
PS 18:0,18:1 can co-drive phase separation with cholesterol in GUVs, and more effectively protect cholesterol from the action of cholesterol oxidase compared with PS 16:0/18:1, PS 18:1/18:1 and PS 16:0/18:2[1].
PS 18:0,18:1 promotes the clustering of endogenous GPI-APs on the surface of PSA3 CHO cells, with an efficacy comparable to that of PS 18:0/18:0 and more potent than that of PS 18:1/18:1 or PS 12:0/12:0[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 321883-23-2
-
Appearance Solid
-
Molecular Weight 812.04
-
Formula C42H79NNaO10P
-
Color White to off-white
-
SMILES
OC([C@@H](N)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O[Na])=O)=O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 1 mg/mL (1.23 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Skotland T, et al. The role of PS 18:0/18:1 in membrane function. Nat Commun. 2019;10(1):2752. Published 2019 Jun 21. [Content Brief]
[2]. Choi J, et al. Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids. Mol Cell Biochem. 2018;442(1-2):187-201. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2315 mL | 6.1573 mL | 12.3147 mL | 30.7867 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
18:0,18:1 PS sodium Related Classifications
HY-148978 Related Classifications
Powered by Bioz