18:0,18:1 PS sodium 

18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage^[1][2].

18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles^[1]:
(1) PS 18:0,18:1 accounts for approximately 22-60% of total PS in various cell lines including PC-3, HEp-2, PSA3 CHO, HeLa, MT4, A549 and mouse fibroblast cell lines.
(2) PS 18:0,18:1 accounts for approximately 40% of total PS species in exosomes derived from PC-3 cells, and theoretically covers about 80% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet^[1].
(3) PS 18:0,18:1 theoretically covers about 60% of the inner leaflet area overlapped by very long-chain sphingolipids on the outer leaflet of HIV-1 particles.

The cross-intercalation between PS 18:0,18:1 and SM d18:1/24:0 is stronger than that between PS 16:0/18:1 (HY-146885), and it is the only tested PS species whose cross-intercalation with SM d18:1/24:0 is enhanced in the presence of cholesterol^[1].
PS 18:0,18:1 can co-drive phase separation with cholesterol in GUVs, and more effectively protect cholesterol from the action of cholesterol oxidase compared with PS 16:0/18:1, PS 18:1/18:1 and PS 16:0/18:2^[1].
PS 18:0,18:1 promotes the clustering of endogenous GPI-APs on the surface of PSA3 CHO cells, with an efficacy comparable to that of PS 18:0/18:0 and more potent than that of PS 18:1/18:1 or PS 12:0/12:0^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

18:0,18:1 PS sodium is highly enriched in rat brain phosphatidylserine relative to heart, kidney, and liver, comprising 26% of total brain phosphatidylserine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

812.04

C₄₂H₇₉NNaO₁₀P

321883-23-2

Solid

White to off-white

OC([C@@H](N)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O[Na])=O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Skotland T, et al. The role of PS 18:0/18:1 in membrane function. Nat Commun. 2019;10(1):2752. Published 2019 Jun 21.  [Content Brief]

  [2]. Choi J, et al. Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids. Mol Cell Biochem. 2018;442(1-2):187-201.  [Content Brief]