124262-93-7
Chemical Structure
18:0,18:1 PS
- CAS No.: 124262-93-7
- Formula:C42H80NO10P
- Molecular Weight:790.06
InChIKey: AJFWREUFUPEYII-PAHWMLEVSA-N
SMILES: OC([C@@H](N)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O)=O
Biological Activity: 18:0,18:1 PS is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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18:0,18:1 PS | 99.95% | 18:0,18:1 PS is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage. | ||||||||||||||||||||
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- [1]. Skotland T, et al. The role of PS 18:0/18:1 in membrane function. Nat Commun. 2019;10(1):2752. Published 2019 Jun 21. [Content Brief]
- [2]. Choi J, et al. Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids. Mol Cell Biochem. 2018;442(1-2):187-201. [Content Brief]
Keywords
