23583-48-4
23583-48-4
Chemical Structure
8-Bromo-cAMP
Synonym(s): 8-Br-Camp
- CAS No.: 23583-48-4
- Formula:C10H11BrN5O6P
- Molecular Weight:408.10
IUPAC Name: (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide
InChIKey: DVKQVRZMKBDMDH-UUOKFMHZSA-N
SMILES: OP1(O[C@@]2([H])[C@@H](O)[C@@H](O[C@]2([H])CO1)N3C(Br)=NC4=C3N=CN=C4N)=O
Biological Activity: 8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells[1][2].
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8-Bromo-cAMP | 99.48% | 8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells. | ||||||||||||||||||||
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References
- [1]. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41. [Content Brief]
- [2]. Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11(41):6538-42. [Content Brief]
Keywords
