1. Stem Cell/Wnt
  2. PKA
  3. 8-Chloro-cAMP

8-Chloro-cAMP 

Cat. No.: HY-123396
Handling Instructions

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity.

For research use only. We do not sell to patients.

8-Chloro-cAMP Chemical Structure

8-Chloro-cAMP Chemical Structure

CAS No. : 41941-56-4

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5 mg USD 1380 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1].

In Vitro

8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.65

Formula

C10H11ClN5O6P

CAS No.
SMILES

ClC(N([[email protected]@]1([H])[[email protected]@H]([[email protected]@]2([H])[[email protected]](COP(O)(O2)=O)([H])O1)O)C3=NC=N4)=NC3=C4N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Product Name:
8-Chloro-cAMP
Cat. No.:
HY-123396
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