Rp-8-Br-cAMPS sodium
Based on 1 Customer Validation
Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS sodium occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS sodium can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS sodium also inhibits insulin secretion.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 925456-59-3
- Formula: C10H10BrN5NaO5PS
- Molecular Weight:446.15
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rp-8-Br-cAMPS (1 mM; 4-6 h) completely blocks the ability of 2-chloroadenosine (HY-W008344) to inhibit LAK cytotoxicity, and significantly reduces the inhibitory effect of 2-chloroadenosine (HY-W008344) on cytokine production[1].
Rp-8-Br-cAMPS (50-100 μM; 2 min) inhibits insulin secretion in 832/13 cells (derived from INS-1 cells)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine leukemia retrovirus RadLV-Rs treated male C57BL/6 mice[3]
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Dosage:1 mg
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Administration:Intraperitoneal injection (i.p.); 10 days
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Result:Had no significant effect on the extent of lymphadenopathy and splenomegaly which is typical of RadLV-Rs retroviral infection.
Strongly increased responses to the anti-CD3 mAb.
Improved T cell responses.
Chemical Information
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CAS No. 925456-59-3
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Appearance Solid
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Molecular Weight 446.15
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Formula C10H10BrN5NaO5PS
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S[Na])=O)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Raskovalova T, et al. Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). Immunol Res. 2006;36(1-3):91-9. [Content Brief]
[2]. Yang S, et al. Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol. 2004 Sep;18(9):2312-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rp-8-Br-cAMPS sodium Related Classifications
HY-137640C Related Classifications
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