Sp-8-Br-cAMPS sodium

Name: Sp-8-Br-cAMPS sodium
Brand: MedChemExpress
SKU: HY-137640A
Rating: 4.5 (0 reviews)

Cat. No.: HY-137640A Purity: 99.9%: Data Sheet
COA

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Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC₅₀ of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve.

For research use only. We do not sell to patients.

Sp-8-Br-cAMPS sodium Chemical Structure

CAS No. : 1573115-90-8

Size	Price	Stock	Quantity
500 μg		In-stock	Estimated Time of Arrival: December 31

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Other Forms of Sp-8-Br-cAMPS sodium:

Rp-8-Br-cAMPS sodium In-stock
Rp-8-Br-cAMPS Get quote
Sp-8-Br-cAMPS Get quote

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PKA PKAR PKACα

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PKA

360 nM (EC₅₀)

In Vitro

Sp-8-Br-cAMPS sodium (0-100 nM) inhibits phagocytosis of X. nematophila and B. subtilis without affecting the number of bacteria per haemocyte type^[1].
Sp-8-Br-cAMPS sodium (0-1000 μM) inhibits Staphylococcal enterotoxin B (SEB)-induced T-cell activation and expressions of cytokines IFN-γ, TNF-α, IL-2, and IL-4 in a dose-dependent manner through activation of PKA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sp-8-Br-cAMPS sodium (50 nM) inhibits protein release from haemocytes, inhibits the bacterial removal from haemolymph without affecting haemocyte viability in G. mellonella larvae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.15

Formula

C₁₀H₁₀BrN₅NaO₅PS

CAS No.

1573115-90-8

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S[Na])=O)O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (56.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2414 mL	11.2070 mL	22.4140 mL
5 mM	0.4483 mL	2.2414 mL	4.4828 mL
10 mM	0.2241 mL	1.1207 mL	2.2414 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.9%

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Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) HNMR (201 KB) RP-HPLC (263 KB) MS (260 KB)

Handling Instructions (2659 KB)

References

[1]. Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83(2):150-9. [Content Brief]

[2]. Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169(2):802-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2414 mL	11.2070 mL	22.4140 mL	56.0350 mL
	5 mM	0.4483 mL	2.2414 mL	4.4828 mL	11.2070 mL
	10 mM	0.2241 mL	1.1207 mL	2.2414 mL	5.6035 mL
	15 mM	0.1494 mL	0.7471 mL	1.4943 mL	3.7357 mL
	20 mM	0.1121 mL	0.5603 mL	1.1207 mL	2.8017 mL
	25 mM	0.0897 mL	0.4483 mL	0.8966 mL	2.2414 mL
	30 mM	0.0747 mL	0.3736 mL	0.7471 mL	1.8678 mL
	40 mM	0.0560 mL	0.2802 mL	0.5603 mL	1.4009 mL
	50 mM	0.0448 mL	0.2241 mL	0.4483 mL	1.1207 mL