Sp-8-Br-cAMPS sodium 

Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC₅₀ of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve^[1][2].

Sp-8-Br-cAMPS sodium (0-100 nM) inhibits phagocytosis of X. nematophila and B. subtilis without affecting the number of bacteria per haemocyte type^[1].
Sp-8-Br-cAMPS sodium (0-1000 μM) inhibits Staphylococcal enterotoxin B (SEB)-induced T-cell activation and expressions of cytokines IFN-γ, TNF-α, IL-2, and IL-4 in a dose-dependent manner through activation of PKA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sp-8-Br-cAMPS sodium (50 nM) inhibits protein release from haemocytes, inhibits the bacterial removal from haemolymph without affecting haemocyte viability in G. mellonella larvae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.15

C₁₀H₁₀BrN₅NaO₅PS

1573115-90-8

BrC(N([C@H]1[C@@H]([C@@]2([H])[C@](COP(S)(O2)=O)([H])O1)O[Na])C3=NC=N4)=NC3=C4N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83(2):150-9.  [Content Brief]

  [2]. Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169(2):802-8.  [Content Brief]