Sp-8-Br-cAMPS sodium
Based on 1 Customer Validation
Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 1573115-90-8
- Formula: C10H10BrN5NaO5PS
- Molecular Weight:446.15
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PKA 360 nM (EC50) |
Sp-8-Br-cAMPS sodium (0-100 nM) inhibits phagocytosis of X. nematophila and B. subtilis without affecting the number of bacteria per haemocyte type[1].
Sp-8-Br-cAMPS sodium (0-1000 μM) inhibits Staphylococcal enterotoxin B (SEB)-induced T-cell activation and expressions of cytokines IFN-γ, TNF-α, IL-2, and IL-4 in a dose-dependent manner through activation of PKA[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1573115-90-8
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Appearance Solid
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Molecular Weight 446.15
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Formula C10H10BrN5NaO5PS
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S[Na])=O)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 25 mg/mL (56.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83(2):150-9. [Content Brief]
[2]. Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169(2):802-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2414 mL | 11.2070 mL | 22.4140 mL | 56.0350 mL |
| 5 mM | 0.4483 mL | 2.2414 mL | 4.4828 mL | 11.2070 mL | |
| 10 mM | 0.2241 mL | 1.1207 mL | 2.2414 mL | 5.6035 mL | |
| 15 mM | 0.1494 mL | 0.7471 mL | 1.4943 mL | 3.7357 mL | |
| 20 mM | 0.1121 mL | 0.5603 mL | 1.1207 mL | 2.8017 mL | |
| 25 mM | 0.0897 mL | 0.4483 mL | 0.8966 mL | 2.2414 mL | |
| 30 mM | 0.0747 mL | 0.3736 mL | 0.7471 mL | 1.8678 mL | |
| 40 mM | 0.0560 mL | 0.2802 mL | 0.5603 mL | 1.4009 mL | |
| 50 mM | 0.0448 mL | 0.2241 mL | 0.4483 mL | 1.1207 mL |
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