2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cyclic AMP

Cyclic AMP  (Synonyms: Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP)

Cat. No.: HY-B1511 Purity: 99.95%
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Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.

For research use only. We do not sell to patients.

CAS No. : 60-92-4

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Based on 25 publication(s) in Google Scholar

Other Forms of Cyclic AMP:

Cyclic AMP Related Antibodies

Top Publications Citing Use of Products

    Cyclic AMP purchased from MedChemExpress. Usage Cited in: J Assist Reprod Genet. 2025 Feb;42(2):665-678.  [Abstract]

    Cyclic AMP (0.5 mM; 4 days). The FOXO1 mRNA expression in T-HESCs transfected with either control vector or FXYD1-overexpression plasmids at 0, 2, and 4 days during decidualization was measured.

    Cyclic AMP purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393.  [Abstract]

    After treating KGN cells with 20 μM of cAMP for 24 h, the expression level of KITL significantly increased.

    Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811.  [Abstract]

    Cyclic AMP (0.5 mM; 14 days) treatment following estrogen (E2) treatment from day 14 onwards in hEOs was measured by quantitative polymerase chain reaction (qPCR).

    Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811.  [Abstract]

    Cyclic AMP (0.5 mM; 14 days). Representative immunofluorescent images showing ESR1 (ER), PGR (PR), and PAEP expression at day 21 and 28 through 28-day treatment in hEOs were obtained.

    Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811.  [Abstract]

    Cyclic AMP (0.5 mM; 14 days). Violin plot of ELISA for secreted PAEP (left) and SPP1 (right) from culture supernatant with different hormone treatments at day 21 in hEOs was shown.

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    Description

    Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes[1][2][3].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Cyclic AMP (Cyclic adenosine monophosphate) modulates mediator generation. Cyclic AMP suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cyclic AMP Related Antibodies
    Molecular Weight

    329.21

    Formula

    C10H12N5O6P
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    0.1 M NaOH : 50 mg/mL (151.88 mM; ultrasonic and adjust pH to 6 with NaOH)

    H2O : 2 mg/mL (6.08 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0376 mL 15.1879 mL 30.3757 mL
    5 mM 0.6075 mL 3.0376 mL 6.0751 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (476 KB)

    COA (252 KB) HNMR (266 KB) CNMR (317 KB) RP-HPLC (267 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / 0.1 M NaOH 1 mM 3.0376 mL 15.1879 mL 30.3757 mL 75.9394 mL
    5 mM 0.6075 mL 3.0376 mL 6.0751 mL 15.1879 mL
    0.1 M NaOH 10 mM 0.3038 mL 1.5188 mL 3.0376 mL 7.5939 mL
    15 mM 0.2025 mL 1.0125 mL 2.0250 mL 5.0626 mL
    20 mM 0.1519 mL 0.7594 mL 1.5188 mL 3.7970 mL
    25 mM 0.1215 mL 0.6075 mL 1.2150 mL 3.0376 mL
    30 mM 0.1013 mL 0.5063 mL 1.0125 mL 2.5313 mL
    40 mM 0.0759 mL 0.3797 mL 0.7594 mL 1.8985 mL
    50 mM 0.0608 mL 0.3038 mL 0.6075 mL 1.5188 mL
    60 mM 0.0506 mL 0.2531 mL 0.5063 mL 1.2657 mL
    80 mM 0.0380 mL 0.1898 mL 0.3797 mL 0.9492 mL
    100 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7594 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Cyclic AMP Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cyclic AMP60-92-4Cyclic adenosine monophosphate Adenosine cyclic 3', 5'-monophosphate cAMPEndogenous Metabolitesecond messengerbiological processesderivativeadenosine triphosphatesignal transductionInhibitorinhibitorinhibit

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