1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. 8-Bromo-cGMP sodium

8-Bromo-cGMP sodium 

Cat. No.: HY-101379A Purity: 99.07%
Handling Instructions

8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses.

For research use only. We do not sell to patients.

8-Bromo-cGMP sodium Chemical Structure

8-Bromo-cGMP sodium Chemical Structure

CAS No. : 51116-01-9

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Solution
10 mM * 1 mL in Water USD 147 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 147 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses[2].

IC50 & Target

Ca2+

 

In Vitro

8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently[3].
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: LLC-PK1 cells (ATCC CL 101)
Concentration: 1-100 μM
Incubation Time: 8 hours
Result: Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%.

Western Blot Analysis[3]

Cell Line: LLC-PK1 cells (ATCC CL 101)
Concentration: 1-100 μM
Incubation Time: 16 hours
Result: Induced the synthesis of HO-1 protein in a concentration-dependent fashion.
In Vivo

8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice[4].
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.08

Formula

C10H10BrN5NaO7P

CAS No.
SMILES

O=C1C2=C(N([[email protected]]3[[email protected]](O)[[email protected]@](OP(OC4)(O[Na])=O)([H])[[email protected]]4([H])O3)C(Br)=N2)NC(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (224.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2418 mL 11.2088 mL 22.4175 mL
5 mM 0.4484 mL 2.2418 mL 4.4835 mL
10 mM 0.2242 mL 1.1209 mL 2.2418 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.07%

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8-Bromo-cGMP sodium
Cat. No.:
HY-101379A
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