8-Bromo-cGMP sodium
Based on 6 publication(s) in Google Scholar
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses.
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- Pureté: 99.89%
- CAS No.: 51116-01-9
- Formule: C10H10BrN5NaO7P
- Masse moléculaire:446.08
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) 8-Bromo-cGMP sodium
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Activité biologique
8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently[3].
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LLC-PK1 cells (ATCC CL 101)
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Concentration:1-100 μM
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Incubation Time:8 hours
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Result:Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%.
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Cell Line:LLC-PK1 cells (ATCC CL 101)
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Concentration:1-100 μM
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Incubation Time:16 hours
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Result:Induced the synthesis of HO-1 protein in a concentration-dependent fashion.
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g)[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51116-01-9
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Appearance Solid
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Masse moléculaire 446.08
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Formule C10H10BrN5NaO7P
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Color Off-white to light yellow
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@@](OP(OC4)(O[Na])=O)([H])[C@]4([H])O3)C(Br)=N2)NC(N)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Mater
A Dual-Action Nucleoside-Based Supramolecular Hydrogel Combats Periodontitis by Disrupting the Bacteria-Osteoclast Cascade. [Abstract]2025 Dec 24:e16181. PMID: 41441772
8-Bromo-cGMP sodium purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Dec 24:e16181. [Abstract]
Functional validation of PKG modulation. Control: multinucleated TRAP (+) cells; 8-Bromo-cGMP sodium (0.1-0.2 mM): reduced OCs formation; KT5823 (PKG inhibitor): Enhanced OCs maturation.
8-Bromo-cGMP sodium purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Dec 24:e16181. [Abstract]
Immunofluorescence of PKG signaling components: Increased expression of: PKG (red) and VASP (red). Cytoskeleton counterstained with FITC (green); Nuclei counterstained with DAPI (blue). 1: Normal control, 2: AP treatment, 3: 8-Bromo-cGMP sodium treatment, 4: KT5823 treatment.
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Nat Metab
2026 Jan;8(1):96-115. PMID: 41507664 -
Free Radic Biol Med
rhBNP inhibited ferroptosis in renal ischemia-reperfusion injury through promoting selenium recycling. [Abstract]2025 Dec 31:245:283-300. PMID: 41482081
8-Bromo-cGMP sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 31:245:283-300. [Abstract]
Cell viability of CCCP-R HK2 cells with rhBNP or 8-Bromo-cGMP sodium (10 μM, pretreatment for 30 minutes) treatment. n = 8 each group.
8-Bromo-cGMP sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 31:245:283-300. [Abstract]
The activity of RhoA measured by G-LISA assay in CCCP-R HK2 cells treated with rhBNP or 8-Bromo-cGMP sodium (10 μM, pretreatment for 30 minutes) treatment.
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Eur J Pharmacol
sGC agonist BAY1021189 promotes thoracic aortic dissection formation by accelerating vascular smooth muscle cell phenotype switch. [Abstract]2023 Aug 5:952:175789. PMID: 37244376 -
Drug Dev Res
Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation. [Abstract]2024 May;85(3):e22192. PMID: 38678552 -
J Biol Chem
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl- currents in the early distal convoluted tubule of the mouse kidney. [Abstract]2026 Jan 23;302(3):111202. PMID: 41581878
8-Bromo-cGMP sodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 23;302(3):111202. [Abstract]
Whole-cell recording shows the effect of ET-1 on NPPB-sensitive Cl- currents in DCT1 in the presence of 1 mM 8-Bromo-cGMP sodium (cGMP analog, blue line), using a ramp protocol. The black line represents the typical NPPB-sensitive Cl- currents. The red line depicts the effect of 8-Bromo-cGMP sodium on the Cl- current. The drug was introduced into the bath 5 to 7 min prior.
Solvant et solubilité
H2O : 100 mg/mL (224.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (224.18 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Sarkar O , et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301. [Content Brief]
[2]. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50. [Content Brief]
[3]. Tobias Polte, et al. Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1. Free Radic Biol Med. 2002 Jan 1;32(1):56-63. [Content Brief]
[4]. Junzo Kamei, et al. Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice. Pain. 2005 Sep;117(1-2):112-20. [Content Brief]
[5]. Elza D van Deel, et al. Vasomotor control in mice overexpressing human endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1144-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2418 mL | 11.2088 mL | 22.4175 mL | 56.0438 mL |
| 5 mM | 0.4484 mL | 2.2418 mL | 4.4835 mL | 11.2088 mL | |
| 10 mM | 0.2242 mL | 1.1209 mL | 2.2418 mL | 5.6044 mL | |
| 15 mM | 0.1495 mL | 0.7473 mL | 1.4945 mL | 3.7363 mL | |
| 20 mM | 0.1121 mL | 0.5604 mL | 1.1209 mL | 2.8022 mL | |
| 25 mM | 0.0897 mL | 0.4484 mL | 0.8967 mL | 2.2418 mL | |
| 30 mM | 0.0747 mL | 0.3736 mL | 0.7473 mL | 1.8681 mL | |
| 40 mM | 0.0560 mL | 0.2802 mL | 0.5604 mL | 1.4011 mL | |
| 50 mM | 0.0448 mL | 0.2242 mL | 0.4484 mL | 1.1209 mL | |
| 60 mM | 0.0374 mL | 0.1868 mL | 0.3736 mL | 0.9341 mL | |
| 80 mM | 0.0280 mL | 0.1401 mL | 0.2802 mL | 0.7005 mL | |
| 100 mM | 0.0224 mL | 0.1121 mL | 0.2242 mL | 0.5604 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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