Guanylyl imidodiphosphate lithium
Based on 1 Customer Validation
Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 64564-03-0
- Formula: C10H13Li4N6O13P3
- Molecular Weight:545.93
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Guanylyl imidodiphosphate lithium (1 mM; 10 min) inhibits the incorporation of [α-32P]GTP into NDP kinase-related guanine nucleotide-binding proteins G1 (reduced to 17.5% of the control group) and G2 (reduced to 24.5% of the control group) derived from HeLa S3 cells[2].
Guanylyl imidodiphosphate lithium (1 mM; 20 min) inhibits the GTPase activity of NDP kinase-related guanine nucleotide-binding proteins G1 and G2 derived from HeLa S3 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 64564-03-0
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Appearance Solid
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Molecular Weight 545.93
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Formula C10H13Li4N6O13P3
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Color White to off-white
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SMILES
O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](N[P](O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)([H])N2C(NC(N)=NC3=O)=C3N=C2
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Synonyms
Gpp(NH)p lithium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 50 mg/mL (91.59 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Abou-Issa H, et al. Modulation of follicle-stimulating hormone-sensitive rat testicular adenylate cyclase activity by guanyl nucleotides. Endocrinology. 1979;104(1):189-193. [Content Brief]
[2]. Ohtsuki K, et al. Characterization of nucleoside-diphosphate kinase-associated guanine nucleotide-binding proteins from HeLa S3 cells. Biochim Biophys Acta. 1986;882(3):322-330. [Content Brief]
[3]. Terry BJ, et al. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate. J Biol Chem. 1980;255(21):10532-10536. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8317 mL | 9.1587 mL | 18.3174 mL | 45.7934 mL |
| 5 mM | 0.3663 mL | 1.8317 mL | 3.6635 mL | 9.1587 mL | |
| 10 mM | 0.1832 mL | 0.9159 mL | 1.8317 mL | 4.5793 mL | |
| 15 mM | 0.1221 mL | 0.6106 mL | 1.2212 mL | 3.0529 mL | |
| 20 mM | 0.0916 mL | 0.4579 mL | 0.9159 mL | 2.2897 mL | |
| 25 mM | 0.0733 mL | 0.3663 mL | 0.7327 mL | 1.8317 mL | |
| 30 mM | 0.0611 mL | 0.3053 mL | 0.6106 mL | 1.5264 mL | |
| 40 mM | 0.0458 mL | 0.2290 mL | 0.4579 mL | 1.1448 mL | |
| 50 mM | 0.0366 mL | 0.1832 mL | 0.3663 mL | 0.9159 mL | |
| 60 mM | 0.0305 mL | 0.1526 mL | 0.3053 mL | 0.7632 mL | |
| 80 mM | 0.0229 mL | 0.1145 mL | 0.2290 mL | 0.5724 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Guanylyl imidodiphosphate lithium Related Classifications
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