Guanylyl Imidodiphosphate trisodium
Based on 1 Customer Validation
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies.
For research use only. We do not sell to patients.
- Purity: 96.72%
- CAS No.: 148892-91-5
- Formula: C10H14N6Na3O13P3
- Molecular Weight:588.14
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Storage:
-80°C, stored under nitrogen
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Guanylyl Imidodiphosphate trisodium (GppNHp) (100 μM) induces the secretion of dense granules from permeabilized platelets in response to calcium ion stimulation, and GTP-Ral enhances the calcium sensitivity of permeabilized platelet dense granule secretion which is inhibited by Sec5-RBD[1].
Guanylyl Imidodiphosphate trisodium (GppNHp) (0.017-333 μM) causes a significant reduction in the lag time required to stimulate adenylate cyclase activity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 148892-91-5
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Appearance Solid
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Molecular Weight 588.14
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Formula C10H14N6Na3O13P3
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Color White to off-white
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SMILES
O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(NP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O3)=C2N=C(N)N1
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Synonyms
Guanosine 5'-[β,γ-imido]triphosphate trisodium
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Shipping
Shipping with dry ice.
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Storage
-80°C, stored under nitrogen
Solvent & Solubility
H2O : 1 mg/mL (1.70 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Mitsunori Kawato, et al. Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J Biol Chem. 2008 Jan 4;283(1):166-174. [Content Brief]
[2]. J Goldberg, et al. Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell. 1998 Oct 16;95(2):237-48. [Content Brief]
[3]. C Gaudin, et al. Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest. 1995 Apr;95(4):1676-83. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7003 mL | 8.5014 mL | 17.0028 mL | 42.5069 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Guanylyl Imidodiphosphate trisodium Related Classifications
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