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KH7 

Cat. No.: HY-103194 Purity: >99.0%
Handling Instructions

KH7 est un inhibiteur spécifique de la adénylyl cyclase soluble (sAC), avec des IC50 de 3-10 μM vers les deux sACt humains purifiés recombinants protéine et sACt exprimés de façon hétérologue dans des tests cellulaires. KH7 est également un inhibiteur de cAMP.

KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.

For research use only. We do not sell to patients.

KH7 Chemical Structure

KH7 Chemical Structure

CAS No. : 330676-02-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 323 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    KH7 purchased from MCE. Usage Cited in: J Cell Physiol. 2020 Jun 11.

    The P‐Akt protein expression is measured by Western blot analysis. The improved effects of PCTR1 on P‐AKT are partially blocked by KH7.
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    Description

    KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1]. KH7 is also a cAMP inhibitor[2].

    IC50 & Target

    IC50: 3-10 μM (recombinant sACt)[1].

    In Vitro

    KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium[1].
    KH7 prevents the generation of CaSF[2].
    In the presence of KH7, the myocytes exerts a negative inotropic effect (NIE) of approximately 20%, suggesting that sAC is involved in the normal generation of basal cardiac contractility[2].

    Molecular Weight

    419.30

    Formula

    C₁₇H₁₅BrN₄O₂S

    CAS No.

    330676-02-3

    SMILES

    CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (238.49 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3849 mL 11.9246 mL 23.8493 mL
    5 mM 0.4770 mL 2.3849 mL 4.7699 mL
    10 mM 0.2385 mL 1.1925 mL 2.3849 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (5.96 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.96 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: >99.0%

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    Keywords:

    KH7KH 7KH-7OthersInhibitorinhibitorinhibit

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    Product Name:
    KH7
    Cat. No.:
    HY-103194
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