2. GPCR/G Protein
  3. Adenylate Cyclase
  4. TDI-11861

TDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor with slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC50 value of 5.5 nM.

For research use only. We do not sell to patients.

TDI-11861 Chemical Structure

TDI-11861 Chemical Structure

CAS No. : 2857049-72-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 871 In-stock
Solution
10 mM * 1 mL in DMSO USD 871 In-stock
Solid
1 mg USD 260 In-stock
5 mg USD 800 In-stock
10 mg USD 1200 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

TDI-11861 Related Antibodies

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Description

TDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor with slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC50 value of 5.5 nM[1].

IC50 & Target

IC50: 5.5 nM (soluble Adenylyl Cyclase)[1]
Molecular Weight

494.92

Formula

C22H25ClF2N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(C2=NN(C=C2CC3=C(C=CC=C3)OCCN4CCOC[C@H]4CO)C(F)F)=CC(Cl)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (101.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0205 mL 10.1026 mL 20.2053 mL
5 mM 0.4041 mL 2.0205 mL 4.0411 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0205 mL 10.1026 mL 20.2053 mL 50.5132 mL
5 mM 0.4041 mL 2.0205 mL 4.0411 mL 10.1026 mL
10 mM 0.2021 mL 1.0103 mL 2.0205 mL 5.0513 mL
15 mM 0.1347 mL 0.6735 mL 1.3470 mL 3.3675 mL
20 mM 0.1010 mL 0.5051 mL 1.0103 mL 2.5257 mL
25 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0205 mL
30 mM 0.0674 mL 0.3368 mL 0.6735 mL 1.6838 mL
40 mM 0.0505 mL 0.2526 mL 0.5051 mL 1.2628 mL
50 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
60 mM 0.0337 mL 0.1684 mL 0.3368 mL 0.8419 mL
80 mM 0.0253 mL 0.1263 mL 0.2526 mL 0.6314 mL
100 mM 0.0202 mL 0.1010 mL 0.2021 mL 0.5051 mL
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TDI-11861 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDI-118612857049-72-8TDI11861TDI 11861Adenylate CyclaseAdenylyl cyclasedissociation ratesADCY10intracellular signalingInhibitorinhibitorinhibit

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