2857049-72-8
Chemical Structure
TDI-11861
- CAS No.: 2857049-72-8
- Formula:C22H25ClF2N6O3
- Molecular Weight:494.92
IUPAC Name: (R)-(4-(2-(2-((3-(2-amino-6-chloropyrimidin-4-yl)-1-(difluoromethyl)-1H-pyrazol-4-yl)methyl)phenoxy)ethyl)morpholin-3-yl)methanol
InChIKey: XVGSKZXXLKUEIO-MRXNPFEDSA-N
SMILES: NC1=NC(C2=NN(C=C2CC3=C(C=CC=C3)OCCN4CCOC[C@H]4CO)C(F)F)=CC(Cl)=N1
Biological Activity: TDI-11861 is an orally active soluble sAC inhibitor optimized and designed based on TDI-10229 (HY-132298), with an IC50 of 3.3 nM and a KD of 1.4 nM. TDI-11861 has advantages such as high affinity, slow dissociation, and good pharmacokinetics. TDI-11861 can be used for research on male contraception and related sAC pharmacology[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TDI-11861 | 99.35% | TDI-11861 is an orally active soluble sAC inhibitor optimized and designed based on TDI-10229 (HY-132298), with an IC50 of 3.3 nM and a KD of 1.4 nM. TDI-11861 has advantages such as high affinity, slow dissociation, and good pharmacokinetics. TDI-11861 can be used for research on male contraception and related sAC pharmacology. | ||||||||||||||||||||
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- [1]. Miller M, et al. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem. 2022 Nov 8. [Content Brief]
- [2]. Kim J, et al. Advances in Male Contraception: When Will the Novel Male Contraception be Available? World J Mens Health. 2024 Jul;42(3):487-501. [Content Brief]
Keywords
