1. GPCR/G Protein
  2. Adenylate Cyclase
  3. TDI-10229

TDI-10229 

Cat. No.: HY-132298
Handling Instructions

TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.

For research use only. We do not sell to patients.

TDI-10229 Chemical Structure

TDI-10229 Chemical Structure

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Description

TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2].

IC50 & Target

IC50: 195 nM (sAC)[2].

In Vitro

TDI-10229 exhibits good permeability with an IC50 of 92 nM for human 4-4 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TDI-10229 (5 mg/kg; p.o.) treatment shows the Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[2]
Dosage: 20 mg/kg
Administration: P.o.(Pharmacokinetic Analysis)
Result: The Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.
Molecular Weight

313.78

Formula

C₁₆H₁₆ClN₅

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
TDI-10229
Cat. No.:
HY-132298
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