2810887-45-5
2810887-45-5
Chemical Structure
TDI-10229
- CAS No.: 2810887-45-5
- Formula:C16H16ClN5
- Molecular Weight:313.78
IUPAC Name: 4-(4-benzyl-1,5-dimethyl-1H-pyrazol-3-yl)-6-chloropyrimidin-2-amine
InChIKey: VSMTYSWGHKYXOF-UHFFFAOYSA-N
SMILES: CC1=C(C(C2=CC(Cl)=NC(N)=N2)=NN1C)CC3=CC=CC=C3
Biological Activity: TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TDI-10229 | 99.00% | TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound. | ||||||||||||||||||||
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References
- [1]. Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054. [Content Brief]
- [2]. Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021;12(8):1283-1287. Published 2021 Jul 14. [Content Brief]
Keywords
