330676-02-3
330676-02-3
Chemical Structure
KH7
- CAS No.: 330676-02-3
- Formula:C17H15BrN4O2S
- Molecular Weight:419.30
IUPAC Name: (E)-2-((1H-benzo[d]imidazol-2-yl)thio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide
InChIKey: WILMXUAKQKGGCC-DJKKODMXSA-N
SMILES: CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O
Biological Activity: KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1]. KH7 is also a cAMP inhibitor[2].
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KH7 | 99.0% | KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor. | ||||||||||||||||||||
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KH7 (Standard) | ≥98% | KH7 (Standard) is the analytical standard of KH7 (HY-103194). This product is intended for research and analytical applications. KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor. | ||||||||||||||||||||
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References
- [1]. Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59. [Content Brief]
- [2]. Han J, et al. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. 4.658J Cell Mol Med. 2020 Mar 11. [Content Brief]
