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  2. Parasite
  3. Bithionol

Bithionol 

Cat. No.: HY-17592 Purity: >99.0%
Handling Instructions

Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.

For research use only. We do not sell to patients.

Bithionol Chemical Structure

Bithionol Chemical Structure

CAS No. : 97-18-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 60 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models. IC50 value: Target: anticaner agent Bithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].

Molecular Weight

356.05

Formula

C₁₂H₆Cl₄O₂S

CAS No.

97-18-7

SMILES

OC1=C(Cl)C=C(Cl)C=C1SC2=CC(Cl)=CC(Cl)=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (92.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8086 mL 14.0430 mL 28.0859 mL
5 mM 0.5617 mL 2.8086 mL 5.6172 mL
10 mM 0.2809 mL 1.4043 mL 2.8086 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

BithionolParasiteInhibitorinhibitorinhibit

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Product name:
Bithionol
Cat. No.:
HY-17592
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