2. Anti-infection
  3. Parasite
    Bacterial
  4. Bithionol

Bithionol 

Cat. No.: HY-17592 Purity: 98.74%
COA Handling Instructions

Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM).

For research use only. We do not sell to patients.

Bithionol Chemical Structure

Bithionol Chemical Structure

CAS No. : 97-18-7

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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Solid
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Other Forms of Bithionol:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma

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  • References

  • Customer Review

Description

Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM)[1][2].

IC50 & Target

Adenylyl cyclase[2]
In Vitro

Bithionol (0.1-10 mg/mL, 72 h) shows toxicity to Neoparamoeba spp parasites in sea water[1].
Bithionol (0-100 μM) inhibits adenylyl cyclase (AC) activity with an IC50 value of 4 μM[2].
Bithionol (50 and 100 μM, 0-10 min) decreases in cAMP formation with essentially complete inhibition of sAC-dependent cAMP accumulation in sAC-overexpressing 4-4 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Bithionol (100 mg/kg/day, oral administration for 12 days) is moderately active against immature H. nana in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immature H. nana infected mice[3]
Dosage: 100 mg/kg/day
Administration: Oral administration, for 12 days post-infection.
Result: Eliminated 48% of mature H. nana. LD50: 760 mg/kg.
Molecular Weight

356.05

Appearance

Solid

Formula

C12H6Cl4O2S
CAS No.
SMILES

OC1=C(Cl)C=C(Cl)C=C1SC2=CC(Cl)=CC(Cl)=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (92.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8086 mL 14.0430 mL 28.0859 mL
5 mM 0.5617 mL 2.8086 mL 5.6172 mL
10 mM 0.2809 mL 1.4043 mL 2.8086 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.74%

COA (250 KB) HNMR (199 KB) RP-HPLC (136 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Bithionol97-18-7ParasiteBacterialInfectioncestodeadenylate cyclaseallostericcAMP4-4 cellInhibitorinhibitorinhibit

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