1. Anti-infection
  2. Parasite
  3. Bithionol sulfoxide

Bithionol sulfoxide 

Cat. No.: HY-17592A Purity: 98.39%
Handling Instructions

Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.

For research use only. We do not sell to patients.

Bithionol sulfoxide Chemical Structure

Bithionol sulfoxide Chemical Structure

CAS No. : 844-26-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 143 In-stock
Estimated Time of Arrival: December 31
500 mg USD 130 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Other Forms of Bithionol sulfoxide:

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Description

Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models. IC50 value: Target: anticaner agent Bithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].

Molecular Weight

372.05

Formula

C₁₂H₆Cl₄O₃S

CAS No.

844-26-8

SMILES

O=S(C1=CC(Cl)=CC(Cl)=C1O)C2=CC(Cl)=CC(Cl)=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (671.95 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6878 mL 13.4391 mL 26.8781 mL
5 mM 0.5376 mL 2.6878 mL 5.3756 mL
10 mM 0.2688 mL 1.3439 mL 2.6878 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Bithionol sulfoxideParasiteInhibitorinhibitorinhibit

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Product Name:
Bithionol sulfoxide
Cat. No.:
HY-17592A
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