1. GPCR/G Protein
    Neuronal Signaling
  2. Adenylate Cyclase
    Adrenergic Receptor
  3. 2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine 

Cat. No.: HY-135878
Handling Instructions

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart.

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2',5'-Dideoxyadenosine Chemical Structure

2',5'-Dideoxyadenosine Chemical Structure

CAS No. : 6698-26-6

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Description

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

IC50 & Target

IC50: 3 µM (adenylyl cyclase)[1]

In Vitro

2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh)[3].
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448[3].
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively[2].

Western Blot Analysis[3]

Cell Line: Primary hippocampal neurons
Concentration: 10 μM
Incubation Time: 30 min
Result: Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
In Vivo

2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats[4].

Animal Model: Male Wistar rats (3-4 months old)[3]
Dosage: 0.1 mg/kg
Administration: IP; 15 min pre-treated
Result: Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats.
Molecular Weight

235.24

Formula

C₁₀H₁₃N₅O₂

CAS No.

6698-26-6

SMILES

C[[email protected]@H]1[[email protected]](C[[email protected]](N2C=NC3=C(N=CN=C32)N)O1)O

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

2',5'-DideoxyadenosineAdenylate CyclaseAdrenergic ReceptorAdenylyl cyclaseBeta ReceptoradenylylcyclaseP-sitenucleosideanalogantiadrenergicheartInhibitorinhibitorinhibit

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2',5'-Dideoxyadenosine
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