1. GPCR/G Protein
    Neuronal Signaling
  2. Adenylate Cyclase
    Adrenergic Receptor
  3. 2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine 

Cat. No.: HY-135878 Purity: 99.86%
Handling Instructions

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart.

For research use only. We do not sell to patients.

2',5'-Dideoxyadenosine Chemical Structure

2',5'-Dideoxyadenosine Chemical Structure

CAS No. : 6698-26-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 105 In-stock
Estimated Time of Arrival: December 31
5 mg USD 95 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 Get quote
100 mg USD 730 Get quote
250 mg USD 1350 Get quote
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1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

IC50 & Target

IC50: 3 µM (adenylyl cyclase)[1]

In Vitro

2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh)[3].
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448[3].
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: Primary hippocampal neurons
Concentration: 10 μM
Incubation Time: 30 min
Result: Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
In Vivo

2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (3-4 months old)[3]
Dosage: 0.1 mg/kg
Administration: IP; 15 min pre-treated
Result: Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats.
Molecular Weight

235.24

Formula

C₁₀H₁₃N₅O₂

CAS No.

6698-26-6

SMILES

C[[email protected]@H]1[[email protected]](C[[email protected]](N2C=NC3=C(N=CN=C32)N)O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (531.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2510 mL 21.2549 mL 42.5098 mL
5 mM 0.8502 mL 4.2510 mL 8.5020 mL
10 mM 0.4251 mL 2.1255 mL 4.2510 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

2',5'-DideoxyadenosineAdenylate CyclaseAdrenergic ReceptorAdenylyl cyclaseBeta ReceptoradenylylcyclaseP-sitenucleosideanalogantiadrenergicheartInhibitorinhibitorinhibit

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Product Name:
2',5'-Dideoxyadenosine
Cat. No.:
HY-135878
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