2. GPCR/G Protein Membrane Transporter/Ion Channel
  3. Adenylate Cyclase Potassium Channel
  4. MDL12330A

MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .

For research use only. We do not sell to patients.

MDL12330A

MDL12330A Chemical Structure

CAS No. : 40297-09-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of MDL12330A:

MDL12330A Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease [1][2][3].

In Vitro

MDL12330A (10 μM) increases insulin secretion and produces prolonged APDs in pancreatic beta cells[1].
MDL-12,330A (10 μM) inhibits KV channels and increases Ca2+ levels in pancreatic beta cells[1].
MDL12330A (10 μM, 30 min) accentuates contractions in uterine rings from rats at mid gestation but not at term gestation or at term gestation in labor[2].
MDL12330A inhibits all cardiac functions in isolated active hearts of guinea pigs with an IC50 of 1.1 μM, including contractile force, dP/dt, dF/dt, pressure development, and activity performance[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDL12330A Related Antibodies
Molecular Weight

377.01

Formula

C23H37ClN2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.C1(/N[C@@H]2[C@H](C3=CC=CC=C3)CCC2)=N/CCCCCCCCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (53.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6524 mL 13.2622 mL 26.5245 mL
5 mM 0.5305 mL 2.6524 mL 5.3049 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

SDS (252 KB)

COA (251 KB) HNMR (492 KB) RP-HPLC (266 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6524 mL 13.2622 mL 26.5245 mL 66.3112 mL
5 mM 0.5305 mL 2.6524 mL 5.3049 mL 13.2622 mL
10 mM 0.2652 mL 1.3262 mL 2.6524 mL 6.6311 mL
15 mM 0.1768 mL 0.8841 mL 1.7683 mL 4.4207 mL
20 mM 0.1326 mL 0.6631 mL 1.3262 mL 3.3156 mL
25 mM 0.1061 mL 0.5305 mL 1.0610 mL 2.6524 mL
30 mM 0.0884 mL 0.4421 mL 0.8841 mL 2.2104 mL
40 mM 0.0663 mL 0.3316 mL 0.6631 mL 1.6578 mL
50 mM 0.0530 mL 0.2652 mL 0.5305 mL 1.3262 mL
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MDL12330A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDL12330A40297-09-4RMI12330AAdenylate CyclasePotassium ChannelAdenylyl cyclaseKcsAadenylate cyclasecyclic adenosine monophosphatemid-gestation uterine ringsinsulin secretionvoltage-dependent Ca2+ channelspotassium channelvoltage-dependent K+ (KV) channelspancreatic beta cellsuterine tissueuterine contractilityInhibitorinhibitorinhibit

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